Database Query Results : , , HNE

HNE, 4-hydroxynonenal (HNE): Click to Expand ⟱
Source:
Type:
HNE is a lipid peroxidation product formed during oxidative stress and is considered both a signaling molecule and a cytotoxic agent depending on its cellular concentration and context.
– HNE is generated as a byproduct of the peroxidation of ω-6 polyunsaturated fatty acids.
– It serves as a marker of oxidative stress and can modify proteins, lipids, and DNA through covalent adduct formation.

• Dual Biological Effects
– At low to moderate concentrations, HNE can act as a signaling molecule, modulating pathways involved in cell proliferation, differentiation, and apoptosis.
– At higher concentrations, HNE is cytotoxic, causing cellular damage and contributing to cell death through protein dysfunction and DNA damage.
– This concentration-dependent activity means that HNE can have both pro-tumorigenic and anti-tumorigenic effects.

– Elevated levels of HNE in tissues or biological fluids are frequently used as indicators of oxidative stress within the tumor microenvironment.
Scientific Papers found: Click to Expand⟱
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *eff↑, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2↓, NF-kB↓,
1571- Cu,    Copper in cancer: From pathogenesis to therapy
- Review, NA, NA
*toxicity↝, ROS↑, lipid-P↓, HNE↑, MAPK↑, JNK↑, AP-1↑, Beclin-1↑, ATG7↑, TumAuto↑, Apoptosis↑, HO-1↑, NQO1↑, mt-ROS↑, Fenton↑,
3924- PTS,    Effect of resveratrol and pterostilbene on aging and longevity
- Review, AD, NA - Review, Stroke, NA
*antiOx↓, *ROS↑, *SOD↑, *GSH↑, *NRF2↑, *MDA↓, *HNE↓, *Inflam↓, *MAPK↓, *IL6↓, *TNF-α↓, *HO-1↑, *cardioP↑, *neuroP↑, *CRM↑, *NLRP3↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 1,   HNE↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   NQO1↑, 1,   ROS↑, 1,   mt-ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

ATG7↑, 1,   Glycolysis↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   JNK↑, 1,   MAPK↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Migration ⓘ

AP-1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 1,   GSH↑, 1,   HNE↓, 2,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NOX4↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 1,   SOD↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis ⓘ

CRM↑, 1,  

Cell Death ⓘ

MAPK↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL6↓, 2,   Inflam↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

GABA↝, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 2,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cardioP↑, 1,   neuroP↑, 2,   toxicity↓, 1,   toxicity↝, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 30

Scientific Paper Hit Count for: HNE, 4-hydroxynonenal (HNE)
1 Carnosine
1 Copper and Cu NanoParticlex
1 Pterostilbene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1137  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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