Database Query Results : , , Cupro

Cupro, Cuproptosis: Click to Expand ⟱
Source:
Type:
Cuproptosis is a recently described form of regulated cell death that is distinct from other types such as apoptosis, necroptosis, and pyroptosis. It is primarily characterized by its direct dependence on copper and its interaction with mitochondrial processes.

-Cuproptosis begins with the intracellular accumulation of copper. This free copper binds directly to lipoylated proteins, which are enzymes involved in important mitochondrial metabolic processes such as the tricarboxylic acid (TCA) cycle.
-Protein Aggregation: The binding of copper to these lipoylated proteins induces their aggregation. This aggregation disrupts normal protein functions and compromises mitochondrial integrity.

Cuproptosis represents a unique form of regulated cell death driven by the accumulation of copper and its consequent interactions with mitochondrial lipoylated proteins.
Scientific Papers found: Click to Expand⟱
1596- Cu,  CDT,    Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review
- Review, NA, NA
TumCD↑, Apoptosis↓, ROS↑, angioG↑, Cupro↑, Paraptosis↑, eff↑, eff↓, selectivity↑, DNAdam↑, eff↑, eff↑, eff↑, eff↑, Fenton↑, H2O2↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑, *toxicity↝, other↑, eff↑,
1572- Cu,    Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
- Review, NA, NA
eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP↑, Apoptosis↑, selectivity↑, eff↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 2,   H2O2↑, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   mtDam↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Cupro↑, 2,   Cyt‑c↑, 1,   Paraptosis↑, 2,   Pyro↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   eff↓, 1,   eff↑, 14,   RadioS↑, 1,   selectivity↑, 2,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↝, 1,  
Total Targets: 1

Scientific Paper Hit Count for: Cupro, Cuproptosis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1139  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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