Database Query Results : , , β-oxidation

β-oxidation, Beta Oxidation: Click to Expand ⟱
Source:
Type:
Beta-oxidation serves as a major pathway for breaking down fatty acids into acetyl-CoA, which then enters the tricarboxylic acid (TCA) cycle to generate ATP.

– In tumors with limited glucose availability or under metabolic stress, enhanced fatty acid oxidation can serve as an alternative energy source, supporting cell survival and proliferation.
– Beta-oxidation contributes to the removal of excess fatty acids and provides substrates for oxidative phosphorylation, thereby influencing the balance between energy production and biosynthetic needs.
– Tumor environments are often hypoxic and nutrient-deprived. Enhanced beta-oxidation can allow cancer cells to adapt by optimizing energy yield from available substrates.

– Upregulated beta-oxidation or reliance on fatty acid metabolism in certain tumors has been correlated with increased aggressiveness, metastasis, and a poor overall prognosis.
Scientific Papers found: Click to Expand⟱
1576- Citrate,    Targeting citrate as a novel therapeutic strategy in cancer treatment
- Review, Var, NA
TCA↓, T-Cell↝, Glycolysis↓, PKM2↓, PFK2?, SDH↓, PDH↓, β-oxidation↓, CPT1A↓, FASN↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, cl‑PARP↑, Hif1a↓, GLUT1↓, angioG↓, Ca+2↓, ROS↓, eff↓, Dose↓, eff↑, Mcl-1↓, HK2↓, IGF-1R↓, PTEN↑, citrate↓, Dose∅, eff↑, eff↑, eff↑, eff↑,
1593- Citrate,    Citrate Induces Apoptotic Cell Death: A Promising Way to Treat Gastric Carcinoma?
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
PFK↓, Glycolysis↓, tumCV↓, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, ATP↓, ChemoSen↑, Mcl-1↓, glucoNG↑, FBPase↑, OXPHOS↓, TCA↓, β-oxidation↓, HK2↓, PDH↓, ROS↑,
2404- SFN,    Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism
- in-vitro, Pca, LNCaP - in-vitro, Pca, 22Rv1 - in-vivo, NA, NA
ACC1↓, FASN↓, CPT1A↓, β-oxidation↓, SREBP1?, HK2↓, PKM2↓, LDHA↓, Glycolysis↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

OXPHOS↓, 1,   ROS↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC1↓, 1,   citrate↓, 1,   CPT1A↓, 2,   FASN↓, 1,   FASN↑, 1,   FBPase↑, 1,   glucoNG↑, 1,   Glycolysis↓, 3,   HK2↓, 3,   LDHA↓, 1,   PDH↓, 2,   PFK↓, 1,   PFK2?, 1,   PKM2↓, 2,   SREBP1?, 1,   TCA↓, 2,   β-oxidation↓, 3,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp2↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Mcl-1↓, 2,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1R↓, 1,   PTEN↑, 1,  

Migration ⓘ

Ca+2↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

T-Cell↝, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↓, 1,   Dose∅, 1,   eff↓, 1,   eff↑, 5,  
Total Targets: 43

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: β-oxidation, Beta Oxidation
2 Citric Acid
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1145  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page