Database Query Results : , , IGFBP7

IGFBP7, Insulin-like Growth Factor Binding Protein 7: Click to Expand ⟱
Source:
Type:
Insulin-like Growth Factor Binding Protein 7 (IGFBP7) is a secreted protein that modulates the actions of insulin-like growth factors (IGFs) and has been implicated in tumorigenesis, angiogenesis, cellular senescence, and apoptosis.

- Reduced expression of IGFBP7 has been associated with tumor progression, whereas in some settings, increased IGFBP7 levels may correlate with an adverse tumor microenvironment or resistance to apoptosis.
- In cancers such as colorectal and thyroid cancer, low IGFBP7 expression has been linked to poorer survival rates and more aggressive disease, supporting a tumor-suppressive role.

Overall, many studies tend to view IGFBP7 as a marker of better prognosis when expressed at normal or high levels, particularly in cases where it enforces cell cycle arrest or senescence.
Scientific Papers found: Click to Expand⟱
1610- EA,    Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer
- Review, Cerv, NA
TumCCA↑, STAT3↓, P21↑, IGFBP7↑, Akt↓, mTOR↓, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Akt↓, 1,   BAX↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGFBP7↑, 1,   mTOR↓, 1,   STAT3↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IGFBP7, Insulin-like Growth Factor Binding Protein 7
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1152  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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