Database Query Results : , , GFR

GFR, glomerular filtration rate: Click to Expand ⟱
Source:
Type:
Glomerular filtration rate—is primarily a clinical measure of kidney function rather than a molecular marker expressed by tumor cells.

GFR as an Indicator of Overall Patient Health and Tolerance to Therapy
– GFR is routinely measured in patients with cancer, especially because many anticancer therapies (such as chemotherapy agents, targeted therapies, and immunotherapies) are renally excreted or can be nephrotoxic.

– Lower GFR has been linked with poorer outcomes in various cancer types (for example, in patients with metastatic cancers, hematologic malignancies, or those undergoing major surgery) because it can limit the dosing and administration of effective therapies.

– Poor kidney function (low GFR) may be an indicator of frailty or overall decreased organ reserve, which in turn can correlate with worse overall survival and increased mortality.
Scientific Papers found: Click to Expand⟱
1658- PBG,    Body Fluid pH Balance in Metabolic Health and Possible Benefits of Dietary Alkaline Foods
- Review, Var, NA
pH↑, GFR↑,
2133- TQ,  CUR,  Cisplatin,    Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signalling
- in-vitro, Nor, HEK293 - in-vivo, NA, NA
*creat↓, *TNF-α↓, *IL6↓, *MRP↓, *GFR↑, *mt-ATPase↑, *p‑Akt↑, *NRF2↑, *HO-1↑, *Casp3↓, *NF-kB↓, *RenoP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cellular Microenvironment ⓘ

pH↑, 1,  

Functional Outcomes ⓘ

GFR↑, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

HO-1↑, 1,   NRF2↑, 1,  

Cell Death ⓘ

p‑Akt↑, 1,   Casp3↓, 1,  

Migration ⓘ

mt-ATPase↑, 1,  

Barriers & Transport ⓘ

MRP↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

creat↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

GFR↑, 1,   RenoP↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: GFR, glomerular filtration rate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1161  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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