Database Query Results : , , PRODH

PRODH, proline dehydrogenase: Click to Expand ⟱
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PRODH (also known as proline oxidase) is a mitochondrial enzyme that catalyzes the first step in proline degradation, linking proline metabolism to energy production and redox regulation.
– PRODH catalyzes the oxidation of proline to pyrroline-5-carboxylate (P5C) within the mitochondria.
– This reaction contributes electrons to the electron transport chain, potentially influencing ATP production.

– Redox Regulation and ROS Generation:
– During proline oxidation, PRODH activity can generate reactive oxygen species (ROS).


– Proline can serve as a source of energy under metabolic stress.
– The enzyme proline dehydrogenase (PRODH) initiates proline catabolism, converting it into pyrroline-5-carboxylate (P5C) and influencing the mitochondrial redox state.
– This process is linked to the generation of reactive oxygen species (ROS), which may either signal adaptive responses or promote apoptosis depending on context.
– Proline metabolism is intertwined with cellular redox balance. PRODH activity can contribute to ROS production, potentially triggering stress responses in tumor cells.

– Upregulation of PRODH and the resultant ROS production can induce apoptosis in some contexts, acting as a tumor suppressive mechanism.
– Elevated PRODH activity or expression can promote ROS generation to levels that trigger apoptosis, thereby limiting tumor growth.
– Some studies have demonstrated that higher PRODH expression in tumor cells is associated with increased apoptosis and potentially better prognosis.

– Strategies that enhance PRODH activity might be harnessed to promote ROS-induced apoptosis in select cancers, whereas in other contexts, inhibiting PRODH might be beneficial if tumor cells rely on its metabolic output under stress conditions.
Scientific Papers found: Click to Expand⟱

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PRODH, proline dehydrogenase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1166  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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