Database Query Results : , , Fibrosis

Fibrosis, Fibrosis: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Causes tissue to overgrow, harden, and scar due to chronic inflammation Chronic fibrosis can create an environment conducive to cancer development. For example, in liver cirrhosis (a form of fibrosis), there is an increased risk of liver cancer (hepatocellular carcinoma). Similarly, pulmonary fibrosis has been associated with an increased risk of lung cancer.

Fibrosis plays a significant role in cancer biology, influencing tumor progression, metastasis, and treatment response. The fibrotic microenvironment can create conditions that support tumor growth and resistance to therapies, often correlating with poor prognosis across various cancer types.
Scientific Papers found: Click to Expand⟱
1206- Caff,    Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices
- in-vitro, NA, NA - ex-vivo, NA, NA
Fibrosis↓, TGF-β↓, α-SMA↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

Fibrosis↓, 1,   TGF-β↓, 1,   α-SMA↓, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Fibrosis, Fibrosis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:117  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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