Database Query Results : , , RenoP

RenoP, K,Renoprotection: Click to Expand ⟱
Source:
Type:
Protects kidneys
-Same as nephroprotective
Opposite is : Nephrotoxicity is toxicity in the kidneys
Scientific Papers found: Click to Expand⟱
2770- AL,    Allicin protects against renal ischemia–reperfusion injury by attenuating oxidative stress and apoptosis
- in-vivo, Nor, NA - in-vitro, Nor, NRK52E
*antiOx↑, *RenoP↑, *MDA↓, *SOD↑,
3456- ALA,    Renal-Protective Roles of Lipoic Acid in Kidney Disease
- Review, NA, NA
*RenoP↑, *ROS↓, *antiOx↑, *Inflam↓, *Sepsis↓, *IronCh↑, *BUN↓, *creat↓, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *chemoP↑, *eff↑, *NF-kB↓,
3541- ALA,    Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology
- Review, Var, NA
*antiOx↑, *IronCh↑, *GSH↑, *BBB↑, Apoptosis↑, MMP↓, ROS↑, lipid-P↑, PARP1↑, Casp3↑, Casp9↑, *NRF2↑, *GSH↑, *ROS↓, RenoP↑, ChemoSen↑, *BG↓,
1999- Api,  doxoR,    Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation
- in-vitro, Nor, NRK52E - in-vitro, Nor, MPC5 - in-vitro, BC, 4T1 - in-vivo, NA, NA
neuroP↑, ChemoSen∅, RenoP↑, selectivity↑, chemoP↑, ROS↑, *ROS∅, *antiOx↑, *toxicity↓,
3689- Ash,    Ashwagandha attenuates TNF-α- and LPS-induced NF-κB activation and CCL2 and CCL5 gene expression in NRK-52E cells
- in-vitro, NA, NRK52E
*RenoP↑, *NF-kB↓, *MCP1↓, *RANTES↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
3170- Ash,    Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms
- in-vitro, Nor, NRK52E - in-vivo, NA, NA
*RenoP↑, *hepatoP↑, *creat↓, *BUN↓, *uricA↓, *Apoptosis↓, *α-SMA↓,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2627- Ba,  Cisplatin,    Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways
RenoP↑, *iNOS↑, *TNF-α↓, *IL6↓, *NF-kB↓, *MAPK↓, *ERK↓, *JNK↓, *antiOx↑, *NRF2↓, *HO-1↑, *Cyt‑c∅, *Casp3∅, *Casp9∅, *PARP∅,
2630- Ba,    Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice
- in-vivo, Nor, NA
*RenoP↑, *uricA↓, *ROS↓, EMT↓,
2628- Ba,  Cisplatin,    Baicalein alleviates cisplatin-induced acute kidney injury by inhibiting ALOX12-dependent ferroptosis
- in-vitro, Nor, HK-2
*RenoP↑, *12LOX↓, *Ferroptosis↓,
2629- Ba,    Baicalein, a Component of Scutellaria baicalensis, Attenuates Kidney Injury Induced by Myocardial Ischemia and Reperfusion
- in-vivo, Nor, NA
*RenoP↑, *Apoptosis↓, *TNF-α↓, *IL1↓, *Bcl-2↑, *BAX↓, *Akt↑,
2701- BBR,    Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice
- in-vivo, Diabetic, NA
*Inflam↓, *antiOx↑, *Ferroptosis↓, *RenoP↑, *DNMT1↓, *DNMTs↓, *KLF4↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2675- BBR,    The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress
- Review, Var, NA
*Inflam↓, *antiOx↑, *ER Stress↓, *cardioP↑, *RenoP↑, *hepatoP↑,
3754- BBR,  CUR,  EGCG,  Hup,    Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: A review
*AChE↓, *Aβ↓, *LDL↓, *RenoP↑, *BChE↓, *eff↑, *BACE↓, *AChE↓, *eff↑,
2760- BetA,    A Review on Preparation of Betulinic Acid and Its Biological Activities
- Review, Var, NA - Review, Stroke, NA
AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1↓, MMP9↓, COX2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,
2725- BetA,    Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice
- in-vivo, Nor, NA
*RenoP↑, *SOD?, *Catalase↑, *GSH↑, *ROS↓, *MDA↓, *IL1β↓, *TNF-α↓, *IL10↓, *IL6↑, *NRF2↑,
3510- Bor,    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *lipid-P↓, *GPx↓, *Catalase↑, *SOD↑, *ALAT↓, *AST↓, *ALP↓,
3502- Bor,    Plasma boron concentrations in the general population: a cross-sectional analysis of cardio-metabolic and dietary correlates
- Review, NA, NA
*Half-Life↑, *VitD↑, *cardioP↑, *RenoP↓,
730- Bor,  Cisplatin,    The Effect of Boric Acid and Borax on Oxidative Stress, Inflammation, ER Stress and Apoptosis in Cisplatin Toxication and Nephrotoxicity Developing as a Result of Toxication
- in-vivo, NA, NA
*ROS↓, *Inflam↓, RenoP↑,
2017- CAP,    Spice Up Your Kidney: A Review on the Effects of Capsaicin in Renal Physiology and Disease
- Review, Var, NA
RenoP↑, AntiTum↑, AMPK↑, mTOR↑, PD-1↓, PD-L1↓,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, eff↑, eff↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, eff↑,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2788- CHr,    Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
- Review, Var, NA
*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,
3994- CoQ10,  Se,    Coenzyme Q10 Supplementation in Aging and Disease
- Review, AD, NA - Review, Park, NA
*AntiAge↑, *cardioP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *QoL↑, *neuroP↑, *Dose↝, *BP↓, *IGF-1↑, *IGFBP1↑, *eff↑, *LDL↓, *HDL↑, *eff↑, *other↑, *RenoP↑, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *other∅,
3225- EGCG,    Epigallocatechin‐3‐Gallate Ameliorates Diabetic Kidney Disease by Inhibiting the TXNIP/NLRP3/IL‐1β Signaling Pathway
- in-vitro, Nor, NA - in-vivo, Nor, NA
*RenoP↑, *NLRP3↓, *TXNIP↓, *ASC↓, *Casp1↓, *IL1β↓, *ROS↓, *TNF-α↓, *IL6↓, *IL18↓,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2↓, IAP2↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2828- FIS,    Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
- Review, Var, NA
*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP↑, ROS↑, cMyc↓, cardioP↑,
2507- H2,    Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis
- in-vivo, NA, NA
*RenoP↑, *ROS↓, *Apoptosis↓, *ER Stress↓, *CHOP↓, *Casp12↓, *GRP78/BiP↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *Beclin-1↑, *p62↓, *mTOR↓,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, eff↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2930- LT,    Luteolin confers renoprotection against ischemia–reperfusion injury via involving Nrf2 pathway and regulating miR320
- in-vitro, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *NRF2↓,
3281- Lyco,  Chemo,    Lycopene Supplementation for Patients Under Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Review, Var, NA
eff↑, cardioP↑, eff?, PSA↓, RenoP↑,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
3531- Lyco,    Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑, *ROS↓, *mtDam↓, *Bcl-2↑, *BAX↓, *Casp9↓, *Casp3↓, *Apoptosis↓, *RenoP↑, *lipid-P↓, *SOD↑, *GPx↑, *Inflam↓, *TNF-α↓, *IL6↓, *IL10↓,
1713- Lyco,    Lycopene: A Potent Antioxidant with Multiple Health Benefits
- Review, Nor, NA
*antiOx↑, *ROS⇅, *Dose↝, *eff↑, *LDL↓, *RenoP↑, *Inflam↓, neuroP↑, Rho↓,
1777- MEL,    Melatonin as an antioxidant: under promises but over delivers
- Review, NA, NA
*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, eff↑,
3842- Moringa,    Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *hepatoP↑, *lipid-P↓, *ALAT↓, *AST↓, *ALP↓, *creat↓, *RenoP↑, NF-kB↓, ChemoSen↑, *memory?,
3844- Moringa,    Review of the Safety and Efficacy of Moringa oleifera
- Review, NA, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
3259- PBG,    Propolis and its therapeutic effects on renal diseases: A review
- Review, Nor, NA
*Inflam↓, *COX2↓, *ROS↓, *NO↓, *NF-kB↓, TumCP↓, angioG↓, VEGF↓, STAT↓, Hif1a↓, RenoP↑, TLR4↓, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *toxicity∅,
3348- QC,    Quercetin and iron metabolism: What we know and what we need to know
- Review, NA, NA
*IronCh↑, *ROS↓, *AntiAg↑, *Fenton↓, *lipid-P↓, *hepatoP↑, *RenoP↑, HIF-1↑, ROS↑,
3059- RES,    Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury
- in-vivo, Nor, HK-2
*RenoP↑, *Inflam↓, *NRF2↑, *HO-1↑, *SIRT1↑, *ROS↓, AntiAge↑,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
1747- RosA,    Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review
- Review, BC, MDA-MB-231 - Review, BC, MDA-MB-468
TumCCA↑, TNF-α↑, GADD45A↑, BNIP3↑, survivin↓, Bcl-2↓, BAX↑, HH↓, eff↑, ChemoSen↑, RadioS↑, TumCP↓, TumCMig↓, Apoptosis↑, RenoP↑, CardioT↓,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
4602- Se,  SNP,  GoldNP,    Advances in nephroprotection: the therapeutic role of selenium, silver, and gold nanoparticles in renal health
- NA, Nor, NA
*ROS↓, *RenoP↑, *Inflam↓,
4450- Se,    Functionalized selenium nanoparticles with nephroprotective activity, the important roles of ROS-mediated signaling pathways
- in-vitro, Kidney, NA
antiOx↑, *ROS↓, RenoP↑,
4445- Se,  DFE,    A comparative study on the hepatoprotective effect of selenium-nanoparticles and dates flesh extract on carbon tetrachloride induced liver damage in albino rats
- in-vivo, LiverDam, NA
*hepatoP↑, *antiOx↑, *AntiCan↑, *BioAv↑, *toxicity↓, *ROS↓, *MDA↓, *ALAT↓, *Albumin↑, *GSH↑, *SOD↑, *RenoP↑,
3191- SFN,    Sulforaphane exhibits potent renoprotective effects in preclinical models of kidney diseases: A systematic review and meta-analysis
- Review, NA, NA
Prot↝, RenoP↑,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, NA, NA
*P-gp↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
3313- SIL,    Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats
- in-vivo, NA, NA
*NRF2↑, *HO-1↑, *creat↓, *BUN↓, *RenoP↑, *MDA↓, *TNF-α↓, *IL1β↓, *Cyt‑c↓, *Casp3↓, *GSTs↓, *GSH↑, *GPx4↑, *SOD↑, *GSR↓, *Ferroptosis↓,
2217- SK,    Shikonin Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis to Attenuate Renal Ischemia/Reperfusion Injury by Activating the Sirt1/Nrf2/HO-1 Pathway
- in-vivo, Nor, NA - in-vitro, Nor, HK-2
*ER Stress↓, *SIRT1↑, *NRF2↑, *HO-1↑, *eff↓, *RenoP↑, *GRP78/BiP↓, *CHOP↓, *Casp12↓, *BAX↓, *cl‑Casp3↓,
2220- SK,    Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *SIRT1↓, *NRF2↑, *HO-1↑, *GSH↑, *TAC↑, *SOD↑, *MDA↓, *NO↓, *iNOS↓, *NHE3↑, *PI3K↑,
2415- SK,    Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways
- in-vivo, Arthritis, NA
Apoptosis?, TumAuto↑, ROS↑, ATP↓, Glycolysis↓, PI3K↓, Akt↓, mTOR↓, *Apoptosis↓, *Inflam↓, *TNF-α↓, *IL6↓, *IL8↓, *IL10↓, *IL17↓, *hepatoP↑, *RenoP↑, PKM2↓, GLUT1↓, HK2↓,
2205- SNP,    Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model
- in-vivo, Nor, NA
*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,
2207- SNP,  TQ,    Protective effects of Nigella sativa L. seeds aqueous extract-based silver nanoparticles on sepsis-induced damages in rats
- in-vivo, Nor, NA
*eff↑, *RenoP↑, *hepatoP↑, *MDA↓, *SOD↑, *GSH↑, *TNF-α↓, *IL1β↓,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, eff↑, DNAdam↑, *iNOS↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
3398- TQ,  5-FU,    Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo
- in-vivo, Nor, NA
*RenoP↑, *TAC↑, *ROS↓, *lipid-P↓, *p38↓, *MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *MDA↓, *GPx↑, *GSR↑, *Catalase↑, *BUN↓, *LDH↓, *IL1β↓,
3400- TQ,  Chemo,    Thymoquinone Ameliorates Carfilzomib-Induced Renal Impairment by Modulating Oxidative Stress Markers, Inflammatory/Apoptotic Mediators, and Augmenting Nrf2 in Rats
- in-vitro, Nor, NA
*GSH↑, *SOD↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *Casp3↓, *Catalase↑, *NRF2↑, *RenoP↑,
3407- TQ,    Thymoquinone and its pharmacological perspective: A review
- Review, NA, NA
*antiOx↑, *ROS↓, *GSTs↑, *GSR↑, *GSH↑, *RenoP↑, *IL1β↓, *TNF-α↓, *MMP13↓, *COX2↓, *PGE2↓, *radioP↑, Twist↓, EMT↓, NF-kB↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, DNMT1↓, HDAC↓,
2126- TQ,    Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway
- Review, Nor, NA
*antiOx↑, *Bacteria↓, *RenoP↑, *hepatoP↑, *neuroP↑, *Inflam↓, *Keap1↓, *NRF2↑, *other↝,
2133- TQ,  CUR,  Cisplatin,    Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signalling
- in-vitro, Nor, HEK293 - in-vivo, NA, NA
*creat↓, *TNF-α↓, *IL6↓, *MRP↓, *GFR↑, *mt-ATPase↑, *p‑Akt↑, *NRF2↑, *HO-1↑, *Casp3↓, *NF-kB↓, *RenoP↑,
2113- TQ,    Potential role of Nigella sativa (NS) in abating oxidative stress-induced toxicity in rats: a possible protection mechanism
- in-vivo, Nor, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *SOD↑, *GSH↑, *ROS↓, *lipid-P↓, ALAT↓, creat↓,
2122- TQ,    Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
- Review, Var, NA
ChemoSen↓, *ROS↓, *GSH↑, RenoP↑, hepatoP↑, COX2↓, NF-kB↓, chemoPv↑, neuroP↑, TumCCA↑, P21↑, p27↑, ROS↑, DNAdam↑, MUC4↓,
2119- TQ,    Dual properties of Nigella Sativa: anti-oxidant and pro-oxidant
- Review, Var, NA
*ROS↓, ROS↑, chemoP↑, RenoP↑, hepatoP↑, NLRP3↓, neuroP↑, NF-kB↓, P21↑, HDAC↓, Apoptosis↑, TumCP↓, GSH↓, GADD45A↑, GSK‐3β↑,
2118- TQ,  Rad,    In vivo radioprotective effects of Nigella sativa L oil and reduced glutathione against irradiation-induced oxidative injury and number of peripheral blood lymphocytes in rats
- in-vivo, Nor, NA
*ROS↓, RenoP↑, hepatoP↑,
2111- TQ,  MTX,    Effect of Nigella sativa (black seeds) against methotrexate-induced nephrotoxicity in mice
- in-vivo, Nor, NA
*RenoP↑, *GSH↑,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *eff↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 72

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ATF3↑, 1,   GSH↓, 1,   GSR↑, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↑, 3,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 2,   ROS↓, 2,   ROS↑, 16,   mt-ROS↑, 1,   SIRT3↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   CDC2↓, 2,   CDC25↓, 4,   mitResp↓, 1,   MMP↓, 7,   MMP↑, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   AMPK↑, 2,   cMyc↓, 2,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 3,   lactateProd↓, 1,   LDH↓, 1,   LDHA↓, 1,   LDL↓, 1,   NADPH↑, 1,   PCK1↓, 1,   PDK1↓, 1,   PKM2↓, 1,   PPARα↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 8,   Akt↑, 1,   p‑Akt↓, 2,   Apoptosis?, 1,   Apoptosis↑, 8,   Bak↑, 1,   BAX↑, 8,   Bcl-2↓, 8,   Bcl-xL↓, 3,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 4,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 3,   cl‑Casp9↑, 3,   cFLIP↓, 1,   Chk2↓, 1,   Chk2↑, 1,   Cyt‑c↑, 8,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 3,   Fas↑, 2,   FasL↑, 1,   HEY1↓, 1,   hTERT/TERT↓, 2,   IAP1↓, 1,   IAP2↓, 1,   iNOS↓, 1,   MAPK↓, 4,   MAPK↑, 1,   Mcl-1↓, 2,   MDM2↓, 1,   p27↑, 2,   p38↑, 1,   p‑p38↓, 1,   survivin↓, 3,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

H3↑, 1,   p‑H3↓, 1,   other↓, 1,   Prot↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 2,   HSP90↓, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   BNIP3↑, 2,   LC3II↑, 1,   LC3s↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

ATM↑, 2,   BRCA1↑, 1,   CHK1↓, 1,   CHK1↑, 1,   DNAdam↑, 3,   DNMT1↓, 2,   DNMT3A↓, 1,   GADD45A↑, 2,   P53↑, 4,   PARP↑, 2,   cl‑PARP↑, 2,   PARP1↑, 1,   PCNA↓, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK2↓, 3,   CDK4↓, 5,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   P21↑, 5,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   p‑cMET↑, 1,   CSCs↓, 1,   EMT↓, 7,   EMT↑, 1,   ERK↓, 5,   p‑ERK↓, 1,   FOXO3↑, 1,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 5,   HDAC1↓, 1,   HDAC4↓, 1,   HH↓, 1,   Let-7↑, 1,   mTOR↓, 5,   mTOR↑, 1,   mTORC1↓, 2,   mTORC2↓, 2,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↑, 2,   PI3K↓, 4,   p‑PI3K↓, 1,   PTEN↑, 1,   RAS↓, 2,   RAS↑, 1,   Shh↓, 1,   SHP1↑, 1,   STAT↓, 1,   STAT3↓, 3,   p‑STAT3↓, 2,   TOP1↓, 1,   TumCG↓, 2,   Wnt↓, 1,  

Migration ⓘ

AP-1↓, 1,   Ca+2↑, 4,   CLDN1↓, 1,   E-cadherin↑, 3,   ER-α36↓, 1,   FAK↓, 2,   Fibronectin↓, 1,   Ki-67↓, 2,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 4,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 5,   MMPs↓, 4,   MUC4↓, 1,   N-cadherin↓, 2,   PDGF↓, 1,   Rho↓, 3,   ROCK1↓, 1,   Slug↓, 2,   Smad1↑, 1,   Snail↓, 2,   TET1↑, 2,   TGF-β↓, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 7,   TumMeta↓, 3,   Twist↓, 5,   uPA↓, 4,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 8,   ATF4↑, 2,   EGFR↓, 3,   HIF-1↑, 1,   Hif1a↓, 4,   PDGFR-BB↓, 1,   VEGF↓, 9,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   COX2↓, 6,   COX2↑, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IL1↓, 1,   IL10↓, 1,   IL1β↓, 2,   IL6↓, 3,   Inflam↓, 2,   JAK1↓, 1,   MCP1↓, 2,   NF-kB↓, 15,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 4,   PSA↓, 1,   TLR4↓, 2,   TNF-α↓, 4,   TNF-α↑, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 2,   ChemoSen↓, 1,   ChemoSen↑, 6,   ChemoSen∅, 1,   Dose↑, 1,   Dose↝, 1,   eff?, 1,   eff↑, 19,   eff↝, 1,   Half-Life↓, 1,   RadioS↑, 2,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 1,   BMPs↑, 1,   BRCA1↑, 1,   creat↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 3,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 3,   Ki-67↓, 2,   LDH↓, 1,   Maspin↑, 1,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 3,   AntiTum↑, 3,   cardioP↑, 4,   CardioT↓, 1,   chemoP↑, 7,   hepatoP↑, 5,   neuroP↑, 6,   radioP↑, 1,   RenoP↑, 19,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 267

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 31,   ARE↑, 1,   Bil↓, 1,   Bil↑, 1,   Catalase↑, 14,   Copper↓, 1,   Fenton↓, 3,   Ferroptosis↓, 4,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 1,   GPx↑, 7,   GPx4↑, 1,   GSH↑, 22,   GSR↓, 1,   GSR↑, 4,   GSTs↓, 1,   GSTs↑, 5,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 15,   HO-1⇅, 1,   Iron↓, 1,   Keap1↓, 2,   lipid-P↓, 16,   MDA↓, 15,   MPO↓, 1,   NOX4↓, 1,   NQO1↑, 3,   NRF2↓, 2,   NRF2↑, 22,   PARK2↑, 1,   Prx↑, 1,   ROS↓, 42,   ROS⇅, 1,   ROS∅, 1,   SOD?, 1,   SOD↑, 19,   SOD2↑, 1,   TAC↑, 4,   uricA↓, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 4,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,   mtDam↓, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   ALAT↓, 9,   p‑AMPK↑, 1,   BUN↓, 4,   cMyc↓, 1,   CRM↑, 1,   LDH↓, 3,   LDL↓, 3,   lipidLev↓, 2,   NADPH↓, 1,   PPARα↑, 1,   PPARγ↑, 1,   SIRT1↓, 1,   SIRT1↑, 3,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↓, 9,   BAX↓, 5,   Bax:Bcl2↓, 1,   Bcl-2↑, 2,   Casp1↓, 1,   Casp12↓, 2,   Casp3?, 1,   Casp3↓, 7,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9∅, 1,   Cyt‑c↓, 1,   Cyt‑c∅, 1,   Fas↓, 1,   Ferroptosis↓, 4,   iNOS↓, 9,   iNOS↑, 2,   JNK↓, 2,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   p‑MAPK↓, 1,   p38↓, 2,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 2,   other∅, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 2,   ER Stress↓, 3,   GRP78/BiP↓, 2,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   MitoP↓, 1,   p62↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNMT1↓, 1,   DNMTs↓, 1,   p16↓, 1,   P53↓, 1,   PARP∅, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 2,   IGF-1↑, 1,   IGFBP1↑, 1,   KLF4↑, 1,   mTOR↓, 1,   neuroG↑, 1,   PI3K↓, 1,   PI3K↑, 1,   STAT3↓, 1,  

Migration ⓘ

AntiAg↑, 2,   mt-ATPase↑, 1,   Ca+2↓, 1,   Ca+2↝, 1,   Cartilage↑, 2,   MMP13↓, 1,   MMP9↓, 1,   PKCδ?, 1,   p‑Rac1↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCP↓, 1,   TXNIP↓, 1,   VCAM-1↓, 2,   α-SMA↓, 2,  

Angiogenesis & Vasculature ⓘ

NO↓, 6,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 3,   MRP↓, 1,   NHE3↑, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   COX2↓, 12,   CRP↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IKKα↑, 1,   IL1↓, 2,   IL10↓, 5,   IL10↑, 1,   IL12↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 15,   IL2↓, 1,   IL4↓, 1,   IL6↓, 15,   IL6↑, 1,   IL8↓, 4,   Inflam↓, 27,   MCP1↓, 1,   MyD88↓, 2,   NF-kB↓, 13,   PGE2↓, 4,   RANTES↓, 1,   TLR2↓, 3,   TLR4↓, 3,   TNF-α↓, 22,   TRIF↓, 1,   VitD↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 4,   BChE↓, 1,   BDNF↑, 1,   ChAT↑, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 5,   BACE↓, 2,   NLRP3↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 3,   Dose↝, 5,   eff↓, 1,   eff↑, 11,   Half-Life↓, 2,   Half-Life↑, 2,   Half-Life↝, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 9,   Albumin↑, 1,   ALP↓, 4,   AST↓, 9,   BG↓, 1,   Bil↓, 1,   Bil↑, 1,   BP↓, 2,   creat↓, 6,   CRP↓, 1,   GutMicro↑, 2,   IL6↓, 15,   IL6↑, 1,   LDH↓, 3,   VitD↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 2,   cardioP↑, 12,   cardioP⇅, 1,   chemoP↑, 3,   cognitive↑, 5,   GFR↑, 1,   hepatoP↑, 22,   memory?, 1,   memory↑, 5,   neuroP↑, 14,   OS↑, 1,   QoL↑, 1,   radioP↑, 4,   RenoP↓, 1,   RenoP↑, 52,   Strength↑, 1,   toxicity↓, 5,   toxicity↝, 1,   toxicity∅, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   IRF3↓, 2,   Sepsis↓, 1,  
Total Targets: 221

Scientific Paper Hit Count for: RenoP, K,Renoprotection
14 Thymoquinone
5 Baicalein
4 Cisplatin
4 Berberine
4 Selenium
4 Lycopene
3 Ashwagandha(Withaferin A)
3 Boron
3 Chrysin
3 Silver-NanoParticles
3 Shikonin
2 Alpha-Lipoic-Acid
2 Curcumin
2 EGCG (Epigallocatechin Gallate)
2 Betulinic acid
2 Fisetin
2 Hydrogen Gas
2 Chemotherapy
2 Moringa oleifera
2 Resveratrol
2 Silymarin (Milk Thistle) silibinin
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 doxorubicin
1 Huperzine A/Huperzia serrata
1 Capsaicin
1 Coenzyme Q10
1 Ferulic acid
1 Honokiol
1 Luteolin
1 Melatonin
1 Propolis -bee glue
1 Quercetin
1 Rosmarinic acid
1 Rutin
1 Gold NanoParticles
1 Date Fruit Extract
1 Sulforaphane (mainly Broccoli)
1 5-fluorouracil
1 Radiotherapy/Radiation
1 methotrexate
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1175  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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