Database Query Results : , , Chl

Chl, chloride: Click to Expand ⟱
Source:
Type:
Chloride ion channels and transporters encompass a diverse family of proteins that help regulate membrane potential, cell volume, and intracellular pH.

-Chloride channels facilitate the movement of chloride ions across cell membranes, contributing to processes such as electrical signaling, regulation of cell volume, and maintenance of intracellular pH.
-They include several families and subtypes, such as the CLC family, volume-regulated anion channels (VRACs), and chloride intracellular channel (CLIC) proteins.
-These channels are involved in cell-cycle regulation, apoptosis, and migration—all processes that can influence tumor growth and metastasis.

-Members of the CLC family (e.g., CLC-3) have been reported to be overexpressed in certain cancers like gliomas, breast cancer, and prostate cancer, where they may contribute to enhanced cellular proliferation and invasiveness.
-Chloride intracellular channel proteins (e.g., CLIC1) have been found to have increased expression in cancers including colorectal, lung, and ovarian carcinomas. Elevated levels of CLIC1, for instance, have been linked to increased tumor aggressiveness.
Scientific Papers found: Click to Expand⟱
1887- DCA,    GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate
- in-vitro, Var, NA
GSTZ1∅, eff↓, PDKs↓, Chl∅, eff↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSTZ1∅, 1,  

Core Metabolism/Glycolysis ⓘ

PDKs↓, 1,  

Migration ⓘ

Chl∅, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 2,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Chl, chloride
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1204  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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