Database Query Results : , , FOSB

FOSB, FOSB: Click to Expand ⟱
Source:
Type:
FOSB—and, more broadly, related AP‐1 family members—in various cancers and their prognostic implications. AP-1 Transcriptional Modulator, Stress Response, and Context-Dependent Effects
Keep in mind that:
• The AP‐1 complex is composed of Fos (including FOSB, c‐Fos, Fra-1, Fra-2) and Jun family proteins, and the prognostic role of any one component (like FOSB) may be context‐ and cancer‐type–dependent.
• In many cases, altered expression (up‐ or down‐regulation) of these proteins has been correlated with tumor progression, metastasis, or response to treatment.
-Where lower levels might be associated with poorer prognosis.
• Some reports indicate that decreased expression of certain AP‐1 proteins (or an imbalance in the complex subunits, including FOSB) may be linked to advanced tumor stages and a poorer outcome.
Scientific Papers found: Click to Expand⟱
3491- MFrot,  MF,    Magnetically controlled cyclic microscale deformation of in vitro cancer invasion models
- in-vitro, BC, MDA-MB-231
Ca+2↑, ATF3↑, FOSB↑,
1950- PL,    Increased Expression of FosB through Reactive Oxygen Species Accumulation Functions as Pro-Apoptotic Protein in Piperlongumine Treated MCF7 Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, Lung, A549
selectivity↑, ROS↑, SETBP1↓, cl‑Casp9↑, eff↓, FOSB↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↑, 1,   ROS↑, 1,  

Cell Death ⓘ

cl‑Casp9↑, 1,  

Transcription & Epigenetics ⓘ

SETBP1↓, 1,  

Migration ⓘ

Ca+2↑, 1,   FOSB↑, 2,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,   selectivity↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FOSB, FOSB
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1214  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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