Database Query Results : , , RANTES

RANTES, CCL5: Click to Expand ⟱
Source:
Type:
RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted), also known as CCL5
• RANTES/CCL5 is a chemokine that plays a central role in recruiting immune cells—such as T cells, eosinophils, and monocytes—to sites of inflammation.
• In the tumor microenvironment, RANTES can influence immune cell infiltration, which may either support anti-tumor responses or, conversely, facilitate a pro-tumorigenic inflammatory milieu depending on the context.
• RANTES is involved in modulating angiogenesis, cell migration, and the deposition of extracellular matrix components. These processes can affect tumor progression and metastasis.

-In several cancer types—including breast, lung, and colorectal cancers—elevated RANTES expression has been associated with more aggressive tumor behavior and, in some instances, poorer prognosis.
Scientific Papers found: Click to Expand⟱
3689- Ash,    Ashwagandha attenuates TNF-α- and LPS-induced NF-κB activation and CCL2 and CCL5 gene expression in NRK-52E cells
- in-vitro, NA, NRK52E
*RenoP↑, *NF-kB↓, *MCP1↓, *RANTES↓,
2481- Ba,  Rad,    Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, KYSE150
12LOX↓, RadioS↑, Dose↝, RANTES↓, MCP1↓,
1976- EGCG,    Epigallocatechin-3-gallate exhibits anti-tumor effect by perturbing redox homeostasis, modulating the release of pro-inflammatory mediators and decreasing the invasiveness of glioblastoma cells
- in-vitro, GBM, U87MG
ROS↑, MMP↓, Casp3↑, Cyt‑c↑, Trx1↓, Ceru↓, IL6↓, IL8↓, MCP1↓, RANTES?, uPA↝, ROS↑,
228- MFrot,  MF,    Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17
- NA, MS, NA
*CD4+↑, *MCP1↓, RANTES↓, *MIP‑1α↓, *Treg lymp↓, *IFN-γ↓, *IL17↓, *CXCc↓,
4036- NAD,  VitB3,    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
- in-vivo, AD, NA
*Inflam↓, *p‑tau↓, *DNAdam↓, *memory↑, *motorD↑, *cognitive↑, *BBB↑, IL1β↓, *TNF-α↓, *MCP1↓, *RANTES↓, *ROS↓, *SIRT3↑, *SIRT6↑,
3012- RosA,  Rad,    Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROSMYPT1TGFβ1 Signaling Via miR-19b-3p
- in-vitro, Nor, IMR90
*Inflam↓, *ROS↓, *p‑NF-kB↓, *Rho↓, *ROCK1↓, *radioP↑, *MCP1↓, *RANTES↓, *ICAM-1↓, *PGC1A↑, *NOX4↓, *Dose↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ceru↓, 1,   ROS↑, 2,   Trx1↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,  

Cell Death ⓘ

Casp3↑, 1,   Cyt‑c↑, 1,  

Migration ⓘ

uPA↝, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   MCP1↓, 2,   RANTES?, 1,   RANTES↓, 2,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

NOX4↓, 1,   ROS↓, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis ⓘ

PGC1A↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   SIRT6↑, 1,  

Migration ⓘ

Rho↓, 1,   ROCK1↓, 1,   Treg lymp↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   CXCc↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL17↓, 1,   Inflam↓, 2,   MCP1↓, 4,   MIP‑1α↓, 1,   NF-kB↓, 1,   p‑NF-kB↓, 1,   RANTES↓, 3,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

p‑tau↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   memory↑, 1,   motorD↑, 1,   radioP↑, 1,   RenoP↑, 1,  
Total Targets: 29

Scientific Paper Hit Count for: RANTES, CCL5
2 Radiotherapy/Radiation
1 Ashwagandha(Withaferin A)
1 Baicalein
1 EGCG (Epigallocatechin Gallate)
1 Magnetic Field Rotating
1 Magnetic Fields
1 nicotinamide adenine dinucleotide
1 Vitamin B3,Niacin
1 Rosmarinic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1221  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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