Database Query Results : , , Histones

Histones, Histones: Click to Expand ⟱
Source:
Type:
Histones play a crucial role in regulating gene expression, and this regulatory mechanism is central to many aspects of brain development, function, and plasticity.

-Histone Acetylation: Often associated with active gene transcription. Enzymes known as histone acetyltransferases (HATs) add acetyl groups that reduce the positive charge on histones, weakening their interaction with the negatively charged DNA and thereby promoting gene expression.
-Histone Methylation: Depending on the specific amino acid residue and the number of methyl groups added, histone methylation can either activate or repress transcription. For instance, methylation on lysine 4 of histone H3 (H3K4me) is commonly linked to gene activation, whereas methylation on lysine 9 (H3K9me) is typically associated with gene repression.
Scientific Papers found: Click to Expand⟱
4981- ATV,    Crosstalk between Statins and Cancer Prevention and Therapy: An Update
Apoptosis↑, selectivity↑, eff↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,
2033- PB,    Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model
- in-vivo, AD, NA
*p‑tau↓, *GSK‐3β↓, *ac‑Histones↑, *neuroP↑,
2203- SK,    Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation
- in-vitro, Lung, NA
TumCP↓, Apoptosis↓, TumCMig↓, TumCI↓, Ferroptosis↑, ERK↓, GPx4↓, 4-HNE↑, ROS↑, GSH↓, ATF3↑, HDAC1↓, ac‑Histones↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

4-HNE↑, 1,   ATF3↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

Histones↝, 1,   ac‑Histones↑, 1,   HMG-CoA↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Apoptosis↑, 1,   Ferroptosis↑, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   HDAC↓, 1,   HDAC1↓, 1,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

OS↑, 1,  
Total Targets: 29

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

ac‑Histones↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,  

Synaptic & Neurotransmission ⓘ

p‑tau↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   neuroP↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: Histones, Histones
1 Atorvastatin
1 Phenylbutyrate
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1232  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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