Database Query Results : , , PAR-2

PAR-2, Protease-activated receptor 2: Click to Expand ⟱
Source:
Type:
Protease-activated receptor 2 (PAR-2), a member of the G protein-coupled receptor family, is activated by proteolytic cleavage.

-Elevated PAR-2 expression and activation in various cancers—including breast, colorectal, pancreatic, prostate, and others—are frequently associated with enhanced tumor invasiveness, a pro-inflammatory microenvironment, and poorer patient outcomes.
Scientific Papers found: Click to Expand⟱
2071- HNK,    Identification of senescence rejuvenation mechanism of Magnolia officinalis extract including honokiol as a core ingredient
- Review, Nor, HaCaT
*ROS↓, *antiOx↑, *AntiAge↑, *MMP↑, *ECAR↓, *Glycolysis↓, *PAR-2↓, *CXCL12↑, *BMAL1↑, *mt-ROS↓, *OXPHOS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   OXPHOS↓, 1,   ROS↓, 1,   mt-ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

BMAL1↑, 1,   ECAR↓, 1,   Glycolysis↓, 1,  

Migration ⓘ

CXCL12↑, 1,  

Immune & Inflammatory Signaling ⓘ

PAR-2↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,  
Total Targets: 11

Scientific Paper Hit Count for: PAR-2, Protease-activated receptor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1246  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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