Database Query Results : , , TKT

TKT, transketolase: Click to Expand ⟱
Source:
Type:
Transketolase is a key enzyme in the non-oxidative arm of the pentose phosphate pathway (PPP), and alterations in its expression or activity can affect cellular metabolism, redox balance, and biosynthetic processes that are critical for rapidly proliferating cancer cells.

– Role: TKT catalyzes the reversible transfer of two-carbon units between sugars in the non-oxidative PPP.
– Impact: By contributing to the generation of ribose-5-phosphate for nucleotide synthesis and influencing the production of NADPH, TKT activity supports both biosynthetic demands and antioxidative defense in tumor cells.
-Alterations in TKT expression can therefore impact the balance between ROS generation and detoxification, influencing cell survival and chemoresistance.
-Inhibition of TKT may thus impair the cell’s antioxidative defenses, leading to a buildup of ROS. Elevated ROS can contribute to oxidative stress, damage cellular components, and in some contexts, even promote cell death.

– Many studies have observed that TKT is upregulated in various malignancies, including lung, breast, colon, and liver cancers.
– Association with Aggressiveness: Elevated TKT expression is often correlated with higher proliferation rates, enhanced anabolic activity, and worse clinical outcomes in some cancer types.
Scientific Papers found: Click to Expand⟱
2177- itraC,    Itraconazole improves survival outcomes in patients with colon cancer by inducing autophagic cell death and inhibiting transketolase expression
- Study, Colon, NA - in-vitro, CRC, COLO205 - in-vitro, CRC, HCT116
OS↑, tumCV↓, Casp3↑, TumCCA↑, HH↓, TumAuto↑, LC3B↑, p62↑, TKT↓,
2332- RES,    Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Review, Var, NA
Glycolysis↓, GLUT1↓, PFK1↓, Hif1a↓, ROS↑, PDH↑, AMPK↑, TumCG↓, TumCI↓, TumCP↓, p‑NF-kB↓, SIRT1↑, SIRT3↑, LDH↓, PI3K↓, mTOR↓, PKM2↓, R5P↝, G6PD↓, TKT↝, talin↓, HK2↓, GRP78/BiP↑, GlucoseCon↓, ER Stress↑, Warburg↓, PFK↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,   SIRT3↑, 1,   TKT↓, 1,   TKT↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   G6PD↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDH↓, 1,   PDH↑, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 1,   R5P↝, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Casp3↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   GRP78/BiP↑, 1,  

Autophagy & Lysosomes ⓘ

LC3B↑, 1,   p62↑, 1,   TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HH↓, 1,   mTOR↓, 1,   PI3K↓, 1,   TumCG↓, 1,  

Migration ⓘ

talin↓, 1,   TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

p‑NF-kB↓, 1,  

Clinical Biomarkers ⓘ

LDH↓, 1,  

Functional Outcomes ⓘ

OS↑, 1,  
Total Targets: 37

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TKT, transketolase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1258  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page