Database Query Results : , , HIF2a

HIF2a, Hypoxia-Inducible Factor 2 alpha: Click to Expand ⟱
Source:
Type:
HIF-2α (Hypoxia-Inducible Factor 2 alpha), also known as EPAS1, is a transcription factor that plays a key role in the cellular response to hypoxia (low oxygen conditions). In cancer, HIF-2α is involved in regulating genes that promote angiogenesis, metabolism, cell proliferation, and survival.

-Tumors often experience hypoxia due to rapid cell growth outpacing vascular supply. This leads to the stabilization and upregulation of HIF-2α.
-Elevated HIF-2α expression has been observed in several cancer types, including renal cell carcinoma, glioma, lung, breast, and colorectal cancers.
Scientific Papers found: Click to Expand⟱
2255- MF,    Pulsed Electromagnetic Fields Induce Skeletal Muscle Cell Repair by Sustaining the Expression of Proteins Involved in the Response to Cellular Damage and Oxidative Stress
- in-vitro, Nor, SkMC
*HSP70/HSPA5↑, *Apoptosis↓, *Inflam↓, *Trx↓, *PONs↓, *SOD2↓, *TumCG↑, *Diff↑, *HIF2a↑, *Cyt‑c↑, P21↑,
3000- PL,    Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
- in-vitro, Nor, HUVECs - in-vitro, Laryn, HEp2
Inflam↓, AntiTum↑, *α-tubulin↓, selectivity↑, HIF2a↓, MCP1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Cycle & Senescence ⓘ

P21↑, 1,  

Angiogenesis & Vasculature ⓘ

HIF2a↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   MCP1↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

SOD2↓, 1,   Trx↓, 1,  

Core Metabolism/Glycolysis ⓘ

PONs↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Cyt‑c↑, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   TumCG↑, 1,  

Migration ⓘ

α-tubulin↓, 1,  

Angiogenesis & Vasculature ⓘ

HIF2a↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  
Total Targets: 11

Scientific Paper Hit Count for: HIF2a, Hypoxia-Inducible Factor 2 alpha
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1274  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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