Database Query Results : , , polyA

polyA, polyamine: Click to Expand ⟱
Source:
Type: marker
Polyamines—organic cations such as putrescine, spermidine, and spermine—play fundamental roles in cell growth and proliferation.

– They are synthesized from amino acid precursors via key enzymes such as ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase.
– Enzymes such as ODC are frequently found to be overexpressed in malignant tissues, driving increased synthesis of polyamines.
– Many cancers exhibit increased polyamine levels, either through upregulated biosynthetic pathways or decreased catabolism.

– Elevated Polyamine Levels: Numerous studies have shown that high levels of polyamines are present in various cancers, including colorectal, prostate, breast, and liver cancers. Measurements can be performed in tumor tissues or in body fluids such as urine, serving as potential non-invasive biomarkers.
Scientific Papers found: Click to Expand⟱
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27↑, Insulin↓, IGF-1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,  

Mitochondria & Bioenergetics ⓘ

Insulin↓, 2,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

polyA↓, 1,   TS↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Bak↑, 1,   Casp9↑, 1,   p27↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   TumCG↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↓, 1,   eff↑, 1,   RadioS↑, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: polyA, polyamine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1277  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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