Database Query Results : , , SXR

SXR, PXR-Steroid and Xenobiotic Receptor: Click to Expand ⟱
Source:
Type:
SXR (Steroid and Xenobiotic Receptor, also known as Pregnane X Receptor, PXR).
-SXR/PXR is a nuclear receptor that is primarily known for its role in detecting and mediating the metabolism and clearance of xenobiotics, drugs, and endogenous compounds.

- Since SXR/PXR regulates drug-metabolizing enzymes and transporters, overexpression in tumor cells may lead to increased metabolism and clearance of anticancer drugs, potentially contributing to chemoresistance.

– Some studies suggest that high SXR/PXR expression might be linked to more aggressive tumor behavior in certain cancers, such as breast, prostate, and gastrointestinal cancers, as it can alter cellular metabolic states and modulate survival pathways.
Scientific Papers found: Click to Expand⟱
2285- VitK2,    New insights into vitamin K biology with relevance to cancer
- Review, Var, NA
Risk↓, AntiCan↑, eff↑, MMP↓, ROS↑, Cyt‑c↑, eff↓, SXR↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Cyt‑c↑, 1,  

Hormonal & Nuclear Receptors ⓘ

SXR↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,   eff↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   Risk↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SXR, PXR-Steroid and Xenobiotic Receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1283  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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