Database Query Results : , , TPI

TPI, Triosephosphate Isomerase: Click to Expand ⟱
Source:
Type:
TPI (Triosephosphate Isomerase)
– TPI is a key glycolytic enzyme that catalyzes the reversible interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P).

– By facilitating glycolysis, TPI plays a crucial role in energy production and metabolic flux in cells.

– Enhanced Glycolytic Activity: Elevated TPI levels can correlate with increased glycolytic flux, supporting the energetic and biosynthetic demands of rapidly proliferating tumor cells.

– Clinical Outcomes: Several studies have suggested that overexpression of TPI may be associated with more aggressive tumor behavior and poorer patient prognosis, though the specific prognostic value can be context- and cancer type–dependent.
Scientific Papers found: Click to Expand⟱
2291- Ba,  BA,    Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Melanoma, A375
LDHA↓, ENO1↓, PKM2↓, GLUT1↓, GLUT3↓, HK2↓, PFK1↓, GPI↓, TPI↓, GlucoseCon↓, TumCG↓, TumCP↓, mTORC1↓, Hif1a↓, Ki-67↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

ENO1↓, 1,   GlucoseCon↓, 1,   GPI↓, 1,   HK2↓, 1,   LDHA↓, 1,   PFK1↓, 1,   PKM2↓, 1,   TPI↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTORC1↓, 1,   TumCG↓, 1,  

Migration ⓘ

Ki-67↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   GLUT3↓, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TPI, Triosephosphate Isomerase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1285  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page