Database Query Results : , , AIM2

AIM2, Absent In Melanoma 2: Click to Expand ⟱
Source:
Type:
AIM2 (Absent In Melanoma 2)
-AIM2 is a cytosolic pattern recognition receptor that belongs to the PYHIN (pyrin and HIN domain) family.
-It is best known for its role in the innate immune system: upon sensing cytosolic double‐stranded DNA, AIM2 forms an inflammasome complex, leading to the activation of caspase-1, secretion of pro-inflammatory cytokines (such as IL-1β and IL-18), and induction of a form of cell death termed pyroptosis.

- AIM2 was initially identified for its reduced expression in melanoma cells compared to normal tissue.
Reduced AIM2 expression in melanoma has been associated with impaired inflammasome activation and a loss of a potential tumor-suppressive function.
In melanoma, downregulation of AIM2 may correlate with a more aggressive tumor phenotype and poorer prognosis, suggesting a protective role in this context.
-In colorectal cancer, studies have noted that AIM2 expression can be lost or diminished in tumor cells.
Lower levels of AIM2 have been associated with increased cell proliferation, reduced apoptosis, and enhanced tumor progression.
Scientific Papers found: Click to Expand⟱
2354- SK,    PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
- in-vivo, Sepsis, NA
PKM2↓, *PKM2↓, *IL1β↓, *IL18↓, *HMGB1↓, *Casp1↓, *NLRP3↓, *AIM2↓, *p‑eIF2α↓, *Sepsis↓,
3127- VitC,    Vitamin C inhibits the activation of the NLRP3 inflammasome by scavenging mitochondrial ROS
- in-vitro, Nor, NA - in-vivo, Nor, NA
*NLRP3↓, *AIM2↓, *mt-ROS↓, *IL1β↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PKM2↓, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

mt-ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

PKM2↓, 1,  

Cell Death ⓘ

Casp1↓, 1,  

Protein Folding & ER Stress ⓘ

p‑eIF2α↓, 1,  

Immune & Inflammatory Signaling ⓘ

AIM2↓, 2,   HMGB1↓, 1,   IL18↓, 1,   IL1β↓, 2,  

Protein Aggregation ⓘ

NLRP3↓, 2,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 10

Scientific Paper Hit Count for: AIM2, Absent In Melanoma 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1294  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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