Database Query Results : , , VM

VM, vasculogenic mimicry: Click to Expand ⟱

Source:

Type:

Vasculogenic mimicry (VM)

-Vasculogenic mimicry refers to the process by which aggressive tumor cells form vascular channel–like structures independently of endothelial cells.
-Unlike classical angiogenesis where new blood vessels develop from preexisting vasculature, VM involves tumor cell plasticity that allows cancer cells to create perfusable networks resembling blood vessels.
-This phenomenon is often observed in highly aggressive and metastatic tumors, reflecting the ability of these cells to adapt to hypoxia and other microenvironmental stresses.

-Tumor regions with low oxygen levels often stimulate VM formation as an adaptive response. Hypoxia promotes a switch in cellular metabolism and gene expression that supports both angiogenesis and vasculogenic mimicry, thus ensuring continued nutrient supply and waste removal.

Scientific Papers found: Click to Expand⟱

2356-

SK,

ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment

in-vitro,

Ovarian,

CaOV3

in-vitro,

Ovarian,

OV90

in-vivo,

NA,

(1 mg/kg) by intraperitoneal injection once every 3 days

mice

PKM2↓, Glycolysis↓, FASN↓, lactateProd↓, Warburg↓, TumCG↓, VM↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

FASN↓, 1, Glycolysis↓, 1, lactateProd↓, 1, PKM2↓, 1, Warburg↓, 1,

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,

Angiogenesis & Vasculature ⓘ

VM↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: VM, vasculogenic mimicry

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells