Database Query Results : , , GTPBP4

GTPBP4, GTP-binding protein 4: Click to Expand ⟱
Source:
Type:
GTPBP4 (GTP-binding protein 4)
GTPBP4 is a member of the GTPase family and is involved in ribosome biogenesis and RNA processing.
Ribosome Biogenesis, Nucleolar Stress, and Proliferation Dependency
-Elevated levels of GTPBP4 are linked to enhanced cell proliferation, which may contribute to tumor aggressiveness.
-Some studies correlate high GTPBP4 expression with poorer clinicopathological outcomes, suggesting its potential as a prognostic marker in breast cancer.
Scientific Papers found: Click to Expand⟱
2357- SK,    GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism
- Study, HCC, NA - in-vivo, NA, NA
AntiTum↑, GTPBP4↓, PKM2↓, lactateProd↓, GlucoseCon↓, Glycolysis↓, E-cadherin↑, TumCG↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   PKM2↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

GTPBP4↓, 1,   TumCG↓, 1,  

Migration ⓘ

E-cadherin↑, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GTPBP4, GTP-binding protein 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1297  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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