Database Query Results : , , FBP1

FBP1, fructose-1,6-bisphosphatase 1: Click to Expand ⟱
Source:
Type:
FBP1 (fructose-1,6-bisphosphatase 1) is a key enzyme in gluconeogenesis

-Loss of FBP1 (often due to promoter hypermethylation) facilitates a metabolic switch in cancer cells—referred to as the “Warburg effect” (whereby cancer cells preferentially use glycolysis over oxidative phosphorylation even in the presence of oxygen). This supports rapid cell proliferation and survival under stress.
-The downregulation of FBP1 may be associated with enhanced tumor growth and poor survival.
Scientific Papers found: Click to Expand⟱
2367- VitD3,    Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia
- in-vivo, AML, NA
FBP1↑, Warburg↓, Glycolysis↓, lactateProd↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

FBP1↑, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   Warburg↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FBP1, fructose-1,6-bisphosphatase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1298  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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