Database Query Results : , , Netrins

Netrins, Netrins: Click to Expand ⟱

Source:

Type:

Netrins genes encode a family of secreted and membrane‐associated proteins that function as chemotropic guidance signals for directing cell and axon migration throughout nervous system development.
Netrin-1 is upregulated in a large fraction of cancers.
The expression of Netrin-1 is markedly reduced or absent in ~50% of brain tumors and prostate cancer, while it is overexpressed in many other cancers.
Netrin family consists primarily of secreted proteins (e.g., Netrin‑1, Netrin‑4) and their receptors (such as DCC [Deleted in Colorectal Cancer] and UNC5 homologues) that guide axonal migration and cell positioning during development. Their roles in cancer are complex and context‑dependent, with some family members acting as tumor promoters and others behaving in a tumor‑suppressive manner.

Scientific Papers found: Click to Expand⟱

191-

MFrot,

MF,

Early exposure of rotating magnetic fields promotes central nervous regeneration in planarian Girardia sinensis

in-vivo,

Nor,

  6 Hz 0.02 T RMFs.

 planarian Girardia sinensis worm

*EGR4↑, *Netrins↑, *NSE↑, *NPY↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Migration ⓘ

Netrins↑, 1,

Angiogenesis & Vasculature ⓘ

EGR4↑, 1, NPY↑, 1,

Clinical Biomarkers ⓘ

NSE↑, 1,
Total Targets: 4

Scientific Paper Hit Count for: Netrins, Netrins

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells