Database Query Results : , , PDHB

PDHB, pyruvate dehydrogenase E1 beta subunit: Click to Expand ⟱
Source:
Type:
PDHB (pyruvate dehydrogenase E1 beta subunit) is a component of the pyruvate dehydrogenase (PDH) complex, which plays a key role in the conversion of pyruvate to acetyl-CoA, thereby linking glycolysis with the tricarboxylic acid (TCA) cycle.

• Many cancers exhibit metabolic reprogramming (the “Warburg effect”), where there is a shift from oxidative phosphorylation to glycolysis. Some studies have reported a downregulation of PDHB in tumors, which may contribute to this shift.
Scientific Papers found: Click to Expand⟱
2387- MET,  GEM,    Metformin Increases the Response of Cholangiocarcinoma Cells to Gemcitabine by Suppressing Pyruvate Kinase M2 to Activate Mitochondrial Apoptosis
- in-vitro, CCA, HCC9810
eff↑, tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, PKM2↓, PDHB↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PDHB↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PDHB, pyruvate dehydrogenase E1 beta subunit
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1301  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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