Database Query Results : , , PKL

PKL, liver isoform of pyruvate kinase: Click to Expand ⟱
Source:
Type:
PKL refers to the liver isoform of pyruvate kinase, an enzyme that catalyzes the final step of glycolysis.

• PKL is normally highly expressed in liver tissue and is involved in efficiently channeling glycolytic intermediates into pyruvate and subsequently into energy production pathways.

• In cancer, metabolic reprogramming (the Warburg effect) is widespread. While many tumors adopt the PKM2 isoform to support rapid proliferation, alterations in PKL expression have been observed particularly in liver cancers, and some extrahepatic tumors where pancreatic or biliary differentiation is involved.
Scientific Papers found: Click to Expand⟱
2402- EA,    Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase
- in-vitro, NA, NA
PKL↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PKL↓, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PKL, liver isoform of pyruvate kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1302  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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