Database Query Results : , , GSDMC

GSDMC, Gasdermin C: Click to Expand ⟱
Source:
Type:
GSDMC (Gasdermin C) is a member of the gasdermin family, proteins that have garnered attention for their role in pyroptosis—a form of programmed cell death associated with inflammation—and for their emerging implications in cancer.

• Several studies have reported dysregulation of GSDMC in a range of tumors. In some cancers, such as colorectal, lung, and gastric cancers, GSDMC expression has been found to be upregulated compared to normal tissue.

• The increased expression of GSDMC in these cancers is thought to be linked not only to cell death pathways but also to the modulation of the tumor microenvironment, potentially influencing tumor progression.

• Elevated GSDMC expression in some cancers has been associated with more aggressive tumor behavior. For instance, higher levels of GSDMC have been correlated with advanced stages, increased metastasis, and poorer overall survival in certain studies.
Scientific Papers found: Click to Expand⟱
2409- PTS,    Pterostilbene Induces Pyroptosis in Breast Cancer Cells through Pyruvate Kinase 2/Caspase-8/Gasdermin C Signaling Pathway
- in-vitro, BC, EMT6 - in-vitro, BC, 4T1 - in-vitro, Nor, HC11
Pyro↑, Glycolysis↓, *toxicity∅, selectivity↑, GSDMC↑, PKM2↓, PKM1↑, GlucoseCon↓, lactateProd↓, ATP↓, TumCG↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   PKM1↑, 1,   PKM2↓, 1,  

Cell Death ⓘ

GSDMC↑, 1,   Pyro↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 1

Scientific Paper Hit Count for: GSDMC, Gasdermin C
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1305  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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