Database Query Results : , , MDMX

MDMX, MDM4: Click to Expand ⟱
Source:
Type:
MDMX (also known as MDM4)

-MDMX, together with its homolog MDM2, is a critical negative regulator of the tumor suppressor protein p53.

-MDMX is often overexpressed in multiple cancer types through gene amplification, transcriptional upregulation, or other post-transcriptional mechanisms.
-Elevated MDMX levels can contribute to an environment of p53 inhibition, even in tumors that retain wild-type p53, thereby supporting cell proliferation and survival.
Scientific Papers found: Click to Expand⟱
2495- Fenb,    Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells
- in-vitro, Melanoma, A375
P53↑, P21↑, TumCCA↑, MDM2↓, MDMX↓, eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

MDM2↓, 1,  

DNA Damage & Repair ⓘ

MDMX↓, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MDMX, MDM4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1313  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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