Database Query Results : , , CoQ10

CoQ10, coenzyme Q10: Click to Expand ⟱
Source:
Type:
CoQ10 (coenzyme Q10) is most widely recognized for its role in mitochondrial bioenergetics and antioxidant defense.
CoQ10 is a key coenzyme for ATP generation that primarily transfers electron from CI and complex II (CII) to CIII in mitochondrial ETC

-It functions as a potent antioxidant, protecting cells from oxidative damage and lipid peroxidation.

-Some studies have suggested that low circulating CoQ10 levels in cancer patients (for example, in breast or colorectal cancer) might be associated with more aggressive disease or poorer overall health status.
-Deficiency of NADH dehydrogenase ubiquinone 1 subunit (Ndufc2), a subunit of CI, has been found in diabetes, cancer, and stroke
Scientific Papers found: Click to Expand⟱
2504- H2,    Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
- Trial, Lung, NA
CD8+↑, As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells
OS↑, Median survival time (MST) for the HGN-treated patients was 28 months, a length that is approximately 3-fold longer than that for NO-treated patients (MST 9 months)
eff↝, (PDT+ ratio and CoQ10 ratio, respectively) revealed that patients with low PDT+ ratio (<0.81) and high CoQ10 ratio (>1.175) had significantly longer OS compared with those with high PDT+ ratio and low CoQ10 ratio
CoQ10↑, Hydrogen gas has been suggested to enhance the clinical efficacy of nivolumab by increasing CoQ10 (mitochondria) to reduce PDT+, with PDT+ and CoQ10 as reliable negative and positive biomarkers of nivolumab, respectively.
PDT+↓,
PGC-1α↑, As hydrogen gas is reported to activate PGC1-α (14), it is also one of the mitochondrial activation mediators.
Dose↝, Patients were continuously treated with nivolumab (1 mg/kg) every 2 weeks. Patients also inhaled hydrogen gas 3 h daily at their home through a cannula or mask that they rented or purchased and connected to a Hycellvator ET 100
*toxicity∅, Recently, hydrogen gas inhalation was used in patients with post-cardiac arrest syndrome, and adverse events were not observed


* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

CoQ10↑, 1,  

Mitochondria & Bioenergetics ⓘ

PGC-1α↑, 1,  

Immune & Inflammatory Signaling ⓘ

PDT+↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↝, 1,  

Functional Outcomes ⓘ

OS↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 1

Scientific Paper Hit Count for: CoQ10, coenzyme Q10
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1315  State#:%  Dir#:%
  wNotes=on  sortOrder:rid,rpid

 

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