Database Query Results : , , CLDN5

CLDN5, Claudin-5: Click to Expand ⟱
Source:
Type:
Claudin-5 is a protein that is part of the claudin family, which plays a crucial role in the formation of tight junctions between cells, particularly in endothelial cells that line blood vessels.
-Tumors often induce changes in claudin-5 expression to enhance their blood supply
Scientific Papers found: Click to Expand⟱
3363- QC,    The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation
- in-vitro, Nor, HBMECs
*Apoptosis↓, *angioG↑, *NRF2↑, *Keap1↓, *ATF6↓, *GRP78/BiP↓, *CLDN5↑, *ZO-1↑, *MMP↑, *BBB↑, *ROS↓, *ER Stress↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Keap1↓, 1,   NRF2↑, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,  

Protein Folding & ER Stress ⓘ

ATF6↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,  

Migration ⓘ

ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   CLDN5↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: CLDN5, Claudin-5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1343  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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