CLDN5 Cancer Research Results

CLDN5, Claudin-5: Click to Expand ⟱
Source:
Type:
Claudin-5 is a protein that is part of the claudin family, which plays a crucial role in the formation of tight junctions between cells, particularly in endothelial cells that line blood vessels.
-Tumors often induce changes in claudin-5 expression to enhance their blood supply
Scientific Papers found: Click to Expand⟱
7557- HYP,    Hyperoside protects the blood-brain barrier from neurotoxicity of amyloid beta 1-42
- in-vitro, AD, NA
*neuroP↑, *Aβ↓, *Casp3↑, *ZO-1↓, *CLDN5↓, *OCLN↓, *MMP2↑, *MMP↓,
3363- QC,    The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation
- in-vitro, Nor, HBMECs
*Apoptosis↓, *angioG↑, *NRF2↑, *Keap1↓, *ATF6↓, *GRP78/BiP↓, *CLDN5↑, *ZO-1↑, *MMP↑, *BBB↑, *ROS↓, *ER Stress↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Keap1↓, 1,   NRF2↑, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   MMP↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,  

Migration(tgid=13) ⓘ

MMP2↑, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CLDN5↓, 1,   CLDN5↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   OCLN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 20

Scientific Paper Hit Count for: CLDN5, Claudin-5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1343  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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