Database Query Results : , , CHIP

CHIP, Clonal Hematopoiesis of Indeterminate Potential: Click to Expand ⟱
Source:
Type:
CHIP refers to the age-related acquisition of somatic mutations in hematopoietic stem cells, leading to clonal expansion of blood cells with these mutations — but without overt hematological malignancy.
-CHIP may actually protect against Alzheimer's disease, which is counterintuitive because CHIP increases systemic inflammation and risk for cardiovascular disease — both of which are risk factors for AD.
Scientific Papers found: Click to Expand⟱
3664- SFN,    Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*CHIP↑, *HSP70/HSPA5↑, *Aβ↓, *tau↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CHIP↑, 1,  

Synaptic & Neurotransmission ⓘ

tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: CHIP, Clonal Hematopoiesis of Indeterminate Potential
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1351  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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