Database Query Results : , , ARE

ARE, antioxidant responsive element (ARE): Click to Expand ⟱
Source:
Type:
antioxidant responsive element (ARE)
ARE in Normal Cells: Protective Role
ARE-regulated genes include NQO1, HO-1, GCLM, GCLC, and various glutathione S-transferases (GSTs).
-Detoxify reactive oxygen species (ROS)
-Agents like sulforaphane (from broccoli) can activate ARE in healthy cells to prevent cancer initiation.
-overactivation in cancer cells aids cancer survival, growth, resistance
Scientific Papers found: Click to Expand⟱
4265- CA,    Potential applications of nanomedicine for treating Parkinson's disease
- Review, Park, NA
*NRF2↑, *ARE↑, *neuroP↑, *motorD↑, *cognitive↑, *SOD↑, *GSR↑, *NGF↑, *BDNF↑,
4333- Cyste,    Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcription
- vitro+vivo, AD, NA
*NRF2↑, *ARE↑, *neuroP↑, *BDNF↑, *GSH↑,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
4801- Lyco,    Lycopene in the Prevention of Cardiovascular Diseases
- Review, CardioV, NA
*BioAv↝, *cardioP↑, *BioAv↑, *BioAv↑, *antiOx↑, *ROS↓, *ARE↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *COX2↓, *Inflam↓, *IL1β↓, *IL6↓, *IL8↑, *TNF-α↓, *NF-kB↓, *BP↓,
4797- Lyco,    A mechanistic updated overview on lycopene as potential anticancer agent
- Review, Var, NA
AntiCan↑, antiOx↓, Apoptosis↓, TumCP↓, TumCCA↑, Risk↓, ROS↓, SOD↑, Catalase↑, GSTs↑, ARE↑, NRF2↑, cycD1/CCND1↓, cycE/CCNE↑, CDK2↑, p27↑, BAX↑, Bcl-2↓, P53↑, ChemoSen↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   ARE↑, 1,   Catalase↑, 1,   GSTs↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   p27↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↑, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↑, 1,   TumCCA↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   Risk↓, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   ARE↑, 4,   Bil↑, 1,   Catalase↑, 2,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 1,   GSH↑, 1,   GSR↑, 1,   HO-1↑, 1,   lipid-P↓, 3,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 3,   ROS↓, 2,   SOD↑, 3,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis ⓘ

PPARγ↑, 1,  

Cell Death ⓘ

iNOS↓, 1,   JNK↓, 1,   p‑MAPK↓, 1,   p38↓, 1,  

Migration ⓘ

Ca+2↓, 1,   VCAM-1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   ICAM-1↓, 1,   IL1β↓, 2,   IL6↓, 2,   IL8↓, 1,   IL8↑, 1,   Inflam↓, 2,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 3,   ChAT↑, 1,   NGF↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   BioAv↝, 1,   Dose↝, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

Bil↑, 1,   BP↓, 1,   GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   motorD↑, 1,   neuroP↑, 3,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,  
Total Targets: 57

Scientific Paper Hit Count for: ARE, antioxidant responsive element (ARE)
2 Lycopene
1 Carnosic acid
1 Cysteamine
1 Ferulic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1354  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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