cGAS–STING Cancer Research Results

cGAS–STING, GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING): Click to Expand ⟱
Source:
Type:
cGAS–STING pathway is primarily associated with neuroinflammation and neuronal damage.
-Studies show upregulated STING in microglia and astrocytes in AD models.
Scientific Papers found: Click to Expand⟱
5511- bemA,    Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation
- in-vitro, Var, NA
ACLY↓, PD-L1↑, mtDam↑, cGAS–STING↑, LDL↓, eff↑,
5988- Chit,    Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways
- Review, Var, NA
DDS↑, *Cartilage↑, *Wound Healing↑, Imm↑, cGAS–STING↑, STAT1↑, NLRP3↑, *DCells↑, *IL10↓, *TGF-β1↓, *TNF-α↓, IL1β↓, ROS↑,
4035- NAD,  VitB3,    NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING
- in-vitro, AD, NA
*Inflam↓, *DNAdam↓, *NLRP3↓, *cGAS–STING↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   LDL↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT1↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   Imm↑, 1,   PD-L1↑, 1,  

Cellular Microenvironment ⓘ

cGAS–STING↑, 2,  

Protein Aggregation ⓘ

NLRP3↑, 1,  

Drug Metabolism & Resistance ⓘ

DDS↑, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

PD-L1↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Migration ⓘ

Cartilage↑, 1,   TGF-β1↓, 1,  

Immune & Inflammatory Signaling ⓘ

DCells↑, 1,   IL10↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment ⓘ

cGAS–STING↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Functional Outcomes ⓘ

Wound Healing↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: cGAS–STING, GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING)
1 bempedoic acid
1 chitosan
1 nicotinamide adenine dinucleotide
1 Vitamin B3,Niacin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1370  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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