Database Query Results : , , MCM2

MCM2, Minichromosome Maintenance Complex Component 2: Click to Expand ⟱
Source:
Type:
Minichromosome Maintenance Complex Component 2 — it’s one of six highly conserved proteins (MCM2–MCM7) that form the MCM helicase complex, which is essential for DNA replication.
MCM2 is overexpressed in many cancers (breast, lung, colon, prostate, brain, etc.), and that overexpression correlates with:
-Increased cell proliferation
-Genomic instability
-Poor prognosis and lower survival rates
Scientific Papers found: Click to Expand⟱
4505- GLA,    Gamma linolenic acid suppresses hypoxia-induced proliferation and invasion of non-small cell lung cancer cells by inhibition of HIF1α
- in-vitro, NSCLC, Calu-1
TumCP↓, PCNA↓, Ki-67↓, MCM2↓, Bcl-2↓, BAX↑, cl‑Casp3↑, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,  

DNA Damage & Repair ⓘ

PCNA↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

MCM2↓, 1,  

Migration ⓘ

Ki-67↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VEGF↓, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MCM2, Minichromosome Maintenance Complex Component 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1378  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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