Database Query Results : , , CLOCK

CLOCK, Circadian Locomotor Output Cycles Kaput: Click to Expand ⟱
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CLOCK (Circadian Locomotor Output Cycles Kaput) is a core circadian-rhythm transcription factor with major roles in cell-cycle control, metabolism, DNA repair, and immune function — all of which influence cancer.
Increasing evidence shows that circadian disruption and altered CLOCK activity can drive tumorigenesis, progression, and therapy resistance.

In many cancers, CLOCK is overexpressed or constitutively active, leading to:
-↑ cell proliferation
-↑ resistance to apoptosis
-↑ survival pathways
-↑ stemness

Cancer stemness often correlates with: ↑ CLOCK expression

Tumor Types Where CLOCK Is Often Upregulated:
Breast, Colorectal, HCC, GBM, NSCLC, Ovarian, Prostate, Pancreatic cancer

Overexpression often correlates with:
-higher grade
-poor differentiation
-worse survival

Natural Products that may modulate CLOCK:
-Melatonin
-Resveratrol
-Curcumin
-EGCG
-Quercetin
-Berberine
-Vitamin D3
-Sulforaphane
-EPA/DHA
-Silymarin/Silibinin
-Honokiol

Indirect Modulation of CLOCK:
-Butyrate (SCFA) – HDAC inhibitor; boosts PER/Cry cycling
-Genistein (soy isoflavone) – alters CLOCK and BMAL1 methylation
-Apigenin – affects BMAL1 and PER2; suppresses cancer growth
-Luteolin – modulates CLOCK through NF-κB/IL-6 pathways

Circadian disruption in cancer and regulation of cancer stem cells by circadian clock genes: An updated review
Potential Role of the Circadian Clock in the Regulation of Cancer Stem Cells and Cancer Therapy
Can we utilise the circadian clock to target cancer stem cells?
Scientific Papers found: Click to Expand⟱
4683- EGCG,    Epigallocatechin-3-gallate inhibits self-renewal ability of lung cancer stem-like cells through inhibition of CLOCK
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vivo, Lung, A549
CSCs↓, CD133↓, CLOCK↓, Wnt↓, β-catenin/ZEB1↓, CD44↓, SOX2↓, Nanog↓, OCT4↓,
4705- MEL,    Melatonin: beyond circadian regulation - exploring its diverse physiological roles and therapeutic potential
- Review, Nor, NA
*CLOCK↝, *BMD↑, *cardioP↑, *neuroP↑, *Sleep↑,
4706- RES,    Resveratrol as a circadian clock modulator: mechanisms of action and therapeutic applications
- Review, Nor, NA
*SIRT1↑, *CLOCK↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CD44↓, 1,   CLOCK↓, 1,   CSCs↓, 1,   Nanog↓, 1,   OCT4↓, 1,   SOX2↓, 1,   Wnt↓, 1,  

Migration ⓘ

β-catenin/ZEB1↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

SIRT1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CLOCK↝, 2,  

Clinical Biomarkers ⓘ

BMD↑, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   neuroP↑, 1,   Sleep↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: CLOCK, Circadian Locomotor Output Cycles Kaput
1 EGCG (Epigallocatechin Gallate)
1 Melatonin
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1390  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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