Database Query Results : , , CTSZ

CTSZ, Cathepsin Z: Click to Expand ⟱
Source:
Type:
CTSZ is best understood as a microglia-enriched, immune–lysosomal gene that contributes to Alzheimer’s disease through neuroinflammatory signaling and lysosomal function, rather than direct amyloid or tau cleavage. Its upregulation reflects—and may amplify—the maladaptive microglial response characteristic of AD.
Scientific Papers found: Click to Expand⟱
4861- Uro,    Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, *Aβ↓, *toxicity↓, *BBB↑, *p‑tau↓, *eff↓, *IL1α↓, *MCP1↓, *MIP‑1α↓, *TNF-α↓, *IL2↓, *SIRT1↓, *DNAdam↓, *Dose↝, *Strength↑, *motorD↑, *CTSZ↓,
4868- Uro,    Urolithin A improves Alzheimer’s disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, *Aβ↓, *tau↓, *MitoP↑, *lysosome↑, *CTSZ↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

SIRT1↓, 1,  

Autophagy & Lysosomes ⓘ

lysosome↑, 1,   MitoP↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

CTSZ↓, 1,   CTSZ↝, 1,   IL1α↓, 1,   IL2↓, 1,   MCP1↓, 1,   MIP‑1α↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↓, 1,  

Functional Outcomes ⓘ

memory↑, 2,   motorD↑, 1,   Strength↑, 1,   toxicity↓, 1,  
Total Targets: 21

Scientific Paper Hit Count for: CTSZ, Cathepsin Z
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1404  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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