Database Query Results : , , DYRK1A

DYRK1A, Dual-specificity tyrosine-phosphorylation-regulated kinase 1A: Click to Expand ⟱
Source:
Type:
DYRK1A is a central, upstream kinase in Alzheimer’s disease that links tau hyperphosphorylation, amyloid production, autophagy/mitophagy impairment, and neuroinflammation. Its overactivity—whether due to aging, stress signaling, or chromosome 21 gene dosage—pushes neurons toward mitochondrial failure and degeneration.
-Increased DYRK1A expression/activity in AD brains
-Strong overexpression in Down syndrome with early-onset AD
Animal models DYRK1A overexpression:
-Increases tau phosphorylation
-Worsens cognitive performance
DYRK1A inhibition:
-Reduces tau pathology
-Improves synaptic and cognitive outcomes
-Enhances autophagic markers



Scientific Papers found: Click to Expand⟱
4872- Uro,    Urolithin A exhibits a neuroprotective effect against Alzheimer's disease by inhibiting DYRK1A activity
- in-vitro, AD, HEK293
*DYRK1A↓, *antiOx↑, *Inflam↓, *neuroP↑, *memory↑, *p‑tau↓, *Aβ↓, *neuroP↑,
4867- Uro,    Urolithin A exhibits a neuroprotective effect against Alzheimer’s disease by inhibiting DYRK1A activity
- in-vivo, AD, NA - in-vitro, AD, HEK293
*neuroP↑, *DYRK1A↓, *memory↑, *p‑tau↓, *Inflam↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Autophagy & Lysosomes ⓘ

DYRK1A↓, 2,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 2,  

Synaptic & Neurotransmission ⓘ

p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Functional Outcomes ⓘ

memory↑, 2,   neuroP↑, 3,  
Total Targets: 7

Scientific Paper Hit Count for: DYRK1A, Dual-specificity tyrosine-phosphorylation-regulated kinase 1A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1407  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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