Database Query Results : , , NTRK

NTRK, NTRK: Click to Expand ⟱

Source:

Type: biomarker

<span class="wphighlight">NTRK</span> and Cancer — Tumor-Agnostic Fusion Drivers, Neurotrophin Signaling, and High-Impact Targeting<br>
<pre>
<span class="wphighlight">NTRK</span> refers to a family of genes encoding tropomyosin receptor kinases (TRKs):
-<span class="wphighlight">NTRK</span>1
-<span class="wphighlight">NTRK</span>2
-<span class="wphighlight">NTRK</span>3

Physiologically, TRKs are activated by neurotrophins (NGF, BDNF, NT-3) and regulate neuronal survival, differentiation, and synaptic plasticity.

Direction of Regulation in Cancer
-Kinase signaling: STRONGLY UPREGULATED
-Not via overexpression or point mutation, but via fusion-mediated activation
This makes <span class="wphighlight">NTRK</span> fusions among the cleanest examples of oncogenic addiction.

<span class="wphighlight">NTRK</span> fusions are rare overall but highly actionable:
-Tumors with <span class="wphighlight">NTRK</span> fusions often show dramatic and durable responses to TRK inhibitors
-Efficacy is independent of tissue of origin
This led to tumor-agnostic drug approvals, a major paradigm shift in oncology.

Cancer Types Where <span class="wphighlight">NTRK</span> Fusions Are Seen
Frequency	            Examples
High (defining event)	    Secretory breast carcinoma, congenital fibrosarcoma, infantile fibrosarcoma
Low (but actionable)	    Lung, colorectal, thyroid, melanoma, sarcoma, glioma

Because prevalence is low in common cancers, screening strategy matters.

<span class="wphighlight">NTRK</span> is therefore a low-frequency, ultra-high-impact biomarker

</pre>

Scientific Papers found: Click to Expand⟱

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: NTRK, NTRK

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  -low or high Dose
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Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1411  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Database Query Results : , , NTRK

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

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