Database Query Results : , , SAL

SAL, specific acetylation level: Click to Expand ⟱
Source:
Type: 
Acetylation is the reversible addition of an acetyl group to lysine residues on histones and many non-histone proteins. It is written by histone acetyltransferases (HATs) and erased by histone deacetylases (HDACs).
-Histone acetylation → relaxed chromatin → gene activation
-Deacetylation → compact chromatin → gene repression

Key writers include EP300 and CREBBP; erasers include multiple HDACs.

Acetylation controls:
-Cell cycle (e.g., acetylation of p53, E2F programs)
-Differentiation vs stemness
-DNA damage response
-Immune visibility (antigen presentation genes)
-Metabolic adaptation (acetylation of metabolic enzymes)

Thus, acetylation is a state regulator, not a single pathway switch.

Therapeutic Relevance
HDAC inhibitors exploit acetylation imbalance to:
-Re-activate silenced genes
-Promote differentiation/apoptosis


Scientific Papers found: Click to Expand⟱
4929- PEITC,  PacT,    Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
ChemoSen↑, Apoptosis↑, TumCCA↑, eff↑, CDK1↓, Bcl-2↓, BAX↑, cl‑PARP↑, SAL↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

SAL↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SAL, specific acetylation level
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1414  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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