Database Query Results : , , HOMA

HOMA, HOMA-IR (Homeostatic Model Assessment of Insulin Resistance): Click to Expand ⟱
Source:
Type:
HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a surrogate index of:
-Insulin resistance
-Compensatory hyperinsulinemia
Functionally, a high HOMA-IR indicates chronic activation of insulin–IGF signaling, which is directly oncogenic.
HOMA-IR < 1.0: Low oncogenic insulin signaling
HOMA-IR 1.5–2.5: Mild risk amplification
HOMA-IR > 2.5–3.0: Sustained oncogenic signaling environment

Reducing HOMA-IR downregulates oncogenic signaling:
-Caloric restriction / fasting
-Exercise (↑ insulin sensitivity, ↑ irisin)
-AMPK activation (e.g., metformin)
-Weight reduction (↓ leptin, ↓ resistin

A high HOMA-IR reflects a pro-cancer signaling state, characterized by:
-PI3K–AKT–mTOR hyperactivation
-Loss of metabolic checkpoints
-Inflammation–hormone synergy


Scientific Papers found: Click to Expand⟱
5061- Ex,    Role of physical exercise in modulating the insulin-like growth factor system for improving breast cancer outcomes: A meta-analysis
- Review, BC, NA
IGF-2↓, IGFBP1↓, HOMA↓, glucose∅, IGF-1∅, eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

HOMA↓, 1,  

Core Metabolism/Glycolysis ⓘ

glucose∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1∅, 1,   IGF-2↓, 1,   IGFBP1↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HOMA, HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1425  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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