Database Query Results : , , Gal1

Gal1, Galectin-1 (LGALS1): Click to Expand ⟱
Source:
Type:
Galectin-1 (Gal-1) is a β-galactoside–binding lectin that recognizes N- and O-linked glycans on cell-surface and extracellular matrix (ECM) proteins. In cancer, Gal-1 is consistently pro-tumorigenic, acting at the intersection of immune suppression, angiogenesis, invasion, and therapy resistance.
-Upregulated in many tumors: glioma, pancreatic, lung, breast (esp. TNBC), colorectal, melanoma, head & neck.
-High Gal-1 correlates with:
  -Advanced stage and metastasis
  -Poor overall survival
  -Resistance to chemo- and radiotherapy

Core Oncogenic Functions
| Rank | Function               | Net Effect |
| ---- | ---------------------- | ---------- |
| 1    | Immune evasion         | ↑          |
| 2    | Angiogenesis           | ↑          |
| 3    | Invasion & metastasis  | ↑          |
| 4    | Therapy resistance     | ↑          |
| 5    | Tumor–stroma crosstalk | ↑          |


Scientific Papers found: Click to Expand⟱
5101- SK,    Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis
- vitro+vivo, CRC, SW-620 - vitro+vivo, CRC, HCT116
Apoptosis↑, TumAuto↑, Gal1↑, TumCP↓, ROS↑, eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

Gal1↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Gal1, Galectin-1 (LGALS1)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1428  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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