Database Query Results : , , CTSS

CTSS, Cathepsin S: Click to Expand ⟱
Source:
Type:
CTSS — Cathepsin S

Primary role: Cysteine protease active at neutral pH; mediator of antigen processing and immune modulation.

Cancer relevance:
CTSS functions both lysosomally and extracellularly, particularly in tumor cells, antigen-presenting cells, and stromal compartments. It alters MHC class II antigen processing, promotes immune evasion, and contributes to angiogenesis and invasion. Unlike other cathepsins, CTSS remains active outside acidic lysosomes, amplifying its effects in the tumor microenvironment.

Net effect in established cancer:
Predominantly pro-tumor, through immune suppression, invasion, and resistance to immunotherapy.
Scientific Papers found: Click to Expand⟱
5124- Sal,    Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance
- in-vitro, BC, NA
CSCs↓, LC3II↑, other↓, lysosome↓, CTSZ↓, CTSB↓, CTSL↓, CTSS↓, autoF↓, TumAuto↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

other↓, 1,  

Autophagy & Lysosomes ⓘ

autoF↓, 1,   LC3II↑, 1,   lysosome↓, 1,   TumAuto↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   CTSB↓, 1,   CTSL↓, 1,   CTSS↓, 1,  

Immune & Inflammatory Signaling ⓘ

CTSZ↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CTSS, Cathepsin S
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1432  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page