Database Query Results : , , TRF2

TRF2, Telomeric Repeat–Binding Factor 2: Click to Expand ⟱
Source:
Type:
TRF2 is a core component of the shelterin complex that caps telomeres and prevents chromosome ends from being recognized as DNA double-strand breaks. In cancer, TRF2 is frequently overexpressed or functionally reprogrammed, enabling unlimited proliferation while suppressing lethal DNA damage responses.
TRF2 Status in Cancer
-Upregulated in many solid tumors (breast, lung, colorectal, glioma, melanoma)
-High TRF2 correlates with:
  -Advanced stage
  -Genomic instability tolerance
  -Poor prognosis
-Often elevated independently of telomerase (TERT)

TRF2 vs Telomerase
| Feature                  | TRF2               | Telomerase (TERT) |
| ------------------------ | ------------------ | ----------------- |
| Function                 | Protects telomeres | Extends telomeres |
| Cancer role              | Hides damage       | Restores length   |
| Required for immortality | Often yes          | Often yes         |
| Can substitute partially | ✔                  | ✔                 |


Scientific Papers found: Click to Expand⟱
5137- ART/DHA,    Autophagy-dependent cell cycle arrest in esophageal cancer cells exposed to dihydroartemisinin
- vitro+vivo, ESCC, Eca109
tumCV↓, TumCCA↑, ROS↑, TumAuto↑, eff↓, TRF2↓, TumCP↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TRF2↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TRF2, Telomeric Repeat–Binding Factor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1435  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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