Database Query Results : , , cystine

cystine, cystine: Click to Expand ⟱
Source:
Type:
Cystine 
-A molecule (amino acid dimer)
-Oxidized form of cysteine (two cysteines linked by a disulfide bond)
-Exists outside the cell in oxidizing environments
-Substrate that cells import to make cysteine → glutathione (GSH)

-GSH precursor
-xCT (SLC7A11)–mediated cystine import


Scientific Papers found: Click to Expand⟱
5138- SAS,  Rad,    Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion
- vitro+vivo, GBM, NA
cystine↓, GSH↓, ROS↑, RadioS↑, eff↓, DNAdam↑, OS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

cystine↓, 1,   GSH↓, 1,   ROS↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,   RadioS↑, 1,  

Functional Outcomes ⓘ

OS↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: cystine, cystine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1436  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page