Database Query Results : , , Hippo

Hippo, Hippo signaling pathway: Click to Expand ⟱
Source: TCGA
Type:
Hippo signaling pathway is a crucial regulatory mechanism that controls cell growth, proliferation, and apoptosis (programmed cell death). It plays a significant role in organ size control and tissue homeostasis.
When the Hippo pathway is active, YAP and TAZ are phosphorylated by LATS1/2, leading to their retention in the cytoplasm and subsequent degradation. When the pathway is inactive, YAP and TAZ translocate to the nucleus, where they promote the expression of genes that drive cell proliferation and inhibit apoptosis.
In many cancers, the Hippo pathway is found to be inactivated, leading to the overactivation of YAP/TAZ. This results in uncontrolled cell growth and survival, contributing to tumorigenesis.
Scientific Papers found: Click to Expand⟱
431- CUR,    Curcumin suppresses the stemness of non-small cell lung cancer cells via promoting the nuclear-cytoplasm translocation of TAZ
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
ALDH1A1↓, CD133↓, EpCAM↓, OCT4↓, TAZ↓, Hippo↑, p‑TAZ↑,
684- EGCG,    Improving the anti-tumor effect of EGCG in colorectal cancer cells by blocking EGCG-induced YAP activation
- in-vitro, CRC, NA
eff↑, Akt↓, VEGFR2↓, STAT3↓, P53↓, Hippo↓, YAP/TEAD↑,
4846- Uro,    Urolithin A exerts anti-tumor effects on gastric cancer via activating autophagy-Hippo axis and modulating the gut microbiota
- in-vivo, GC, NA
TumCG↓, Hippo↑, Warburg↓, Apoptosis↑, GutMicro↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Hippo↓, 1,   Hippo↑, 2,   YAP/TEAD↑, 1,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   CD133↓, 1,   EpCAM↓, 1,   OCT4↓, 1,   STAT3↓, 1,   TAZ↓, 1,   p‑TAZ↑, 1,   TumCG↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGFR2↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Hippo, Hippo signaling pathway
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:144  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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