Database Query Results : , , MKK7

MKK7, MAP2K7/MKK7: Click to Expand ⟱
Source:
Type:
MKK7 (also called MAP2K7) is a dual-specificity MAP kinase kinase that selectively activates the JNK (c-Jun N-terminal kinase) pathway. In cancer, MKK7 is a context-dependent stress signaling node that can drive apoptosis and tumor suppression or support adaptation, inflammation, and therapy resistance, depending on signal strength, duration, and cellular background.
Frequently dysregulated rather than simply up- or down-regulated
Observed patterns:
-Loss or suppression → reduced stress-induced apoptosis
-Chronic low-level activation → inflammation, survival signaling
MKK7 is a cell-fate switch, not a growth driver.
Cancer survives by blunting or reshaping MKK7–JNK signaling so that stress no longer triggers mitochondrial commitment to death. When MKK7 signaling is restored or sharpened, cancer cells often become highly vulnerable.
Scientific Papers found: Click to Expand⟱
5187- PEITC,    Phenethyl Isothiocyanate Inhibits Migration and Invasion of Human Gastric Cancer AGS Cells through Suppressing MAPK and NF-κB Signal Pathways
- in-vitro, GC, AGS
TumMeta↓, ERK↓, MKK7↓, PKCδ↓, Rho↓, uPA↓, MMP2↓, MMP9↓, RAS↓, VEGF↓, FAK↓, iNOS↓, COX2↓, TumCP↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MKK7↓, 1,  

Cell Death ⓘ

iNOS↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   RAS↓, 1,  

Migration ⓘ

FAK↓, 1,   MMP2↓, 1,   MMP9↓, 1,   PKCδ↓, 1,   Rho↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   uPA↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MKK7, MAP2K7/MKK7
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1441  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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