Database Query Results : , , COL11A1

COL11A1, Collagen Type XI Alpha 1: Click to Expand ⟱
Source:
Type:
COL11A1 encodes a minor fibrillar collagen normally restricted to cartilage and embryonic tissues. In cancer, its aberrant re-expression marks a desmoplastic, invasive tumor microenvironment (TME) and is one of the strongest stromal signatures of aggressive disease.
Expression Pattern & Prognostic Value
-Highly upregulated in tumor stroma, especially cancer-associated fibroblasts (CAFs)
-Common across: pancreatic ductal adenocarcinoma, ovarian, colorectal, gastric, lung, breast (basal-like)
-High COL11A1 = poor prognosis, advanced stage, metastasis, therapy resistance
-Rarely expressed by normal adult epithelia → excellent specificity as a cancer-stroma marker

More predictive of aggressiveness than many tumor-intrinsic markers
Often co-expressed with COL1A1, COL10A1, FN1, and LOX


Scientific Papers found: Click to Expand⟱
5242- MFrot,    Rotating magnetic field downregulating type XI collagen to suppress triple-negative breast cancer metastasis by inactivating the ITGB1/FAK/YAP signaling pathway
- in-vitro, BC, NA
TumCI↓, COL11A1↓, TumCG↓, TumMeta↓, ITGB1↓, FAK↓, YAP/TEAD↓, Dose↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

YAP/TEAD↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

COL11A1↓, 1,   FAK↓, 1,   ITGB1↓, 1,   TumCI↓, 1,   TumMeta↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: COL11A1, Collagen Type XI Alpha 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1444  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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