Database Query Results : , , H3K4

H3K4, : Click to Expand ⟱
Source:
Type:
H3K4 refers to the lysine-4 residue on histone H3 and, in practice, to its methylation states (H3K4me1, H3K4me2, H3K4me3). These are among the most important epigenetic marks in cancer, because they define which genes are transcriptionally competent.

H3K4 is an epigenetic “gatekeeper of expression.”
Cancer exploits H3K4 methylation to keep growth and survival genes accessible, while metabolic stress (e.g., methionine restriction) selectively destabilizes this system. It is not simply “up” or “down” — it is repatterned.
Scientific Papers found: Click to Expand⟱
129- CUR,    Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation
- vitro+vivo, Pca, LNCaP
JNK↓, H3K4↓, TumCG↓, Apoptosis↑, eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

H3K4↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   JNK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: H3K4, 
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1445  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page