Database Query Results : , , JAK3

JAK3, Janus kinase 3: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
A member of the Janus kinase family of enzymes, which play a crucial role in the signaling pathways of various cytokines and growth factors. JAK3 is primarily expressed in hematopoietic (blood-forming) cells and is involved in the signaling of several interleukins, particularly those that are important for immune function.
Mutations in the JAK3 gene can lead to constitutive activation of the pathway, promoting uncontrolled cell proliferation and survival.
Scientific Papers found: Click to Expand⟱
464- CUR,    Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p/STAT3 axis
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, TPC-1
TumCI↓, TumCI↓, MMP2↓, MMP9↓, EMT↓, STAT3↓, miR-301a-3p↓, STAT↓, N-cadherin↓, Vim↓, Fibronectin↓, p‑JAK↓, p‑JAK2↓, p‑JAK3↓, p‑STAT1↓, p‑STAT2↓, E-cadherin↑,
3377- QC,    Quercetin inhibits a large panel of kinases implicated in cancer cell biology
PDGF↓, FLT3↓, JAK3↓, MET↓, RET↓, FGFR2↓, other↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Kinase & Signal Transduction ⓘ

RET↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   FGFR2↓, 1,   FLT3↓, 1,   STAT↓, 1,   p‑STAT1↓, 1,   p‑STAT2↓, 1,   STAT3↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   Fibronectin↓, 1,   MET↓, 1,   miR-301a-3p↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   PDGF↓, 1,   TumCI↓, 2,   Vim↓, 1,  

Immune & Inflammatory Signaling ⓘ

p‑JAK↓, 1,   p‑JAK2↓, 1,   JAK3↓, 1,   p‑JAK3↓, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: JAK3, Janus kinase 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:165  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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