PolI Cancer Research Results

PolI, RNA Polymerase I: Click to Expand ⟱
Source:
Type:

RNA Polymerase I - DNA-Directed RNA Polymerase I

Abbreviation: RNA Pol I, Pol I, RNAPI

Type: Nuclear DNA-dependent RNA polymerase / ribosomal RNA transcription complex

Function: RNA polymerase I transcribes the 47S precursor ribosomal RNA, which is processed to generate 18S, 5.8S, and 28S rRNAs. Pol I activity is concentrated in the nucleolus and is a major regulator of ribosome biogenesis, protein-synthesis capacity, cell growth, and proliferation.

Cancer: ↑ Frequently hyperactivated in cancer. Increased Pol I-dependent rRNA transcription supports elevated ribosome biogenesis and protein synthesis required for rapid tumor-cell growth. Oncogenic pathways including MYC can stimulate Pol I transcription, while tumor suppressors including TP53 and RB normally restrain ribosome biogenesis. Pharmacological inhibition of Pol I can induce nucleolar stress and suppress tumor growth.
Scientific Papers found: Click to Expand⟱
Showing Research Papers: 0 to 0 of 0

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PolI, RNA Polymerase I
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1702  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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