PolII Cancer Research Results

PolII, RNA Polymerase II: Click to Expand ⟱
Source:
Type:

RNA Polymerase II - DNA-Directed RNA Polymerase II

Abbreviation: RNA Pol II, Pol II, RNAPII

Type: Nuclear DNA-dependent RNA polymerase / transcription complex

Function: RNA polymerase II transcribes essentially all protein-coding genes as precursor mRNAs as well as numerous non-coding RNAs. Its transcriptional cycle is regulated by general transcription factors, Mediator, chromatin regulators, and phosphorylation of the C-terminal domain of its largest subunit, POLR2A, particularly through transcription-associated kinases including CDK7, CDK9, and CDK12.

Cancer: ↕ Dysregulated / transcriptionally dependent. Cancer cells frequently become highly dependent on RNA polymerase II-mediated transcription to maintain expression of oncogenes, survival proteins, and short-lived transcriptional programs. Direct or indirect inhibition of Pol II transcription, including inhibition of CDK7 or CDK9, can preferentially suppress transcriptionally addicted cancer cells. A universal increase in Pol II expression itself is not characteristic of all cancers.
Scientific Papers found: Click to Expand⟱
Showing Research Papers: 0 to 0 of 0

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PolII, RNA Polymerase II
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1703  State#:%  Dir#:%
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